2. Gene
  3. MDK - midkine Gene

MDK - midkine Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：中期因子

种属: Homo sapiens

同用名: MK; ARAP; NEGF2

基因 ID: 4192 | 基因类型: protein coding

关于 MDK

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:46,380,784-46,383,837 (from NCBI)

This gene has 12 transcripts (splice variants), 247 orthologues and 1 paralogue. Broad expression in ovary (RPKM 88.5), endometrium (RPKM 55.5) and 14 other tissues.

功能概要

该基因编码一个分泌性生长因子家族的成员，该家族可结合肝素并对视黄酸产生反应。编码的蛋白质促进细胞生长、迁移和血管生成，特别是在肿瘤发生过程中。该基因已被靶向作为多种不同疾病的治疗剂。已经观察到编码多种同种型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]

MDK 基因产物(6)

mRNA Protein Name
NM_001012333.3 NP_001012333.1 midkine isoform a precursor
NM_001012334.2 NP_001012334.1 midkine isoform a precursor
NM_001270550.1 NP_001257479.1 midkine isoform a precursor
NM_001270551.3 NP_001257480.1 midkine isoform a precursor
NM_001270552.3 NP_001257481.1 midkine isoform b precursor
NM_002391.6 NP_002382.1 midkine isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables heparan sulfate binding IDA
IDA: 通过直接分析推断
12084985 GOA
enables heparin binding IDA
IDA: 通过直接分析推断
9384573 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
10212223 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular signal transduction IDA
IDA: 通过直接分析推断
18469519 GOA
involved in leukocyte chemotaxis involved in inflammatory response IMP
IMP: 通过突变表型推断
10683378 GOA
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: 通过突变表型推断
19060126 GOA
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
12573468 GOA
involved in negative regulation of regulatory T cell differentiation IMP
IMP: 通过突变表型推断
22323540 GOA
involved in positive regulation of blood vessel branching IMP
IMP: 通过突变表型推断
19060126 GOA
involved in positive regulation of cell adhesion IDA
IDA: 通过直接分析推断
12084985 GOA
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
15466886 GOA
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
18469519 GOA
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
22323540 GOA
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
22323540 GOA
involved in positive regulation of keratinocyte proliferation IDA
IDA: 通过直接分析推断
18469519 GOA
involved in positive regulation of leukocyte cell-cell adhesion IMP
IMP: 通过突变表型推断
24458438 GOA
involved in positive regulation of macrophage chemotaxis IMP
IMP: 通过突变表型推断
10683378 GOA
involved in positive regulation of neuron migration IMP
IMP: 通过突变表型推断
10212223 GOA
involved in positive regulation of neuron projection development IDA
IDA: 通过直接分析推断
12084985 GOA
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
15466886 GOA
involved in positive regulation of oligodendrocyte differentiation IDA
IDA: 通过直接分析推断
27445335 GOA
involved in positive regulation of smooth muscle cell chemotaxis IMP
IMP: 通过突变表型推断
10683378 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MDK 蛋白结构

PTN_MK_N

PTN_MK_N: PTN/MK heparin-binding protein family, N-terminal domain (24 - 80)

PTN_MK_C

PTN_MK_C: PTN/MK heparin-binding protein family, C-terminal domain (81 - 143)

  • 0
  • 100
  • 143 a.a.
蛋白主名 其他名称

midkine

amphiregulin-associated protein

MDK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MDK P21741 TMED8 Homo sapiens Q6PL24
Validated Y2H
32296183
种属内
MDK P21741 MIEF2 Homo sapiens Q96C03-3
Validated Y2H
32296183
种属内
MDK P21741 JOSD2 Homo sapiens Q8TAC2
Validated Y2H
32296183
种属内
MDK P21741 RBFA Homo sapiens Q8N0V3
Validated Y2H
32296183
种属内
MDK P21741 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
32296183
种属内
MDK P21741 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
种属内
MDK P21741 NFU1 Homo sapiens Q9UMS0
Validated Y2H
32296183
种属内
MDK P21741 PBX3 Homo sapiens Q96AL5
Validated Y2H
32296183
种属内
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属内
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
MDK P21741 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
MDK P21741 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MDK 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73295 MDK Protein, Human (sf9) P21741-1 (V21-D143) ≥95%
HY-P700138AF Animal-Free MDK Protein, Human (His) P21741-1 (V21-D143) ≥95%
HY-P700791 MDK/Midkine Protein, Human (His-Avi) P21741-1 (V21-D143) ≥95%
HY-P701024 MDK/Midkine Protein, Human (Biotinylated, His-Avi) P21741-1 (V21-D143) ≥95%

关联疾病

疾病名称 别名
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-110171 iMDK Inhibitor 99.35% 否
HY-110171A iMDK quarterhydrate Inhibitor 99.37% 否
HY-18633 MDK83190 Activator 98.40% 否
HY-119467 MDK0734 / 否
HY-RS08262 MDK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MDK RGD RGD:69073
Mus musculus MDK MGD MGI:96949
Felis catus MDK VGNC VGNC:68222
Bos taurus MDK VGNC VGNC:49556
Others MDK NCBI
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