ART4 - ADP-ribosyltransferase 4 (inactive) (Dombrock blood group) Gene

中文名称：ADP-核糖基转移酶 4 (无活性) (Dombrock 血型)

种属: Homo sapiens

同用名: DO; DOK1; ARTC4; CD297; DO/ART4

关于 ART4

功能概要

该基因编码的蛋白质包含单-ADP-核糖基化 (ART) 基序。它是 ADP-核糖基转移酶基因家族的成员，但酶活性尚未通过实验证明。 Dombrock 血型系统的抗原位于基因产物上，该基因产物是锚定在红细胞膜上的糖基磷脂酰肌醇。已知等位基因变异，其中一些会导致不良输血反应。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]