MMP19 - matrix metallopeptidase 19 Gene

中文名称：基质金属肽酶 19

种属: Homo sapiens

同用名: CODA; MMP18; RASI-1

基因 ID: 4327 | 基因类型: protein coding

关于 MMP19

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:55,835,433-55,842,936 (from NCBI)

This gene has 9 transcripts (splice variants), 246 orthologues, 23 paralogues and is associated with 2 phenotypes. Broad expression in gall bladder (RPKM 58.3), appendix (RPKM 21.2) and 19 other tissues.

功能概要

该基因编码的蛋白质家族成员参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。编码的蛋白质作为无活性的前蛋白分泌，在被细胞外蛋白酶切割后被激活。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 1 月]

This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

MMP19 基因产物(3)

mRNA	Protein	Name
NM_001272101.2	NP_001259030.1	matrix metalloproteinase-19 isoform 3 preproprotein
NM_001414375.1	NP_001401304.1	matrix metalloproteinase-19 isoform 4 preproprotein
NM_002429.6	NP_002420.1	matrix metalloproteinase-19 isoform 1 preproprotein

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables metalloendopeptidase activity	EXP EXP: 通过实验结果推断	10809722	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MMP19 蛋白结构

PG_binding_1

Peptidase_M10

Hemopexin

0
100
200
300
400
508 a.a.

蛋白主名

其他名称

matrix metalloproteinase-19

matrix metalloproteinase RASI

重组 MMP19 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75929	MMP-19 Protein, Human	Q99542-1 (L101-G256)	≥95%

关联疾病

疾病名称

别名

Cavitary Optic Disc Anomalies

Familial Cavitary Optic Disc Anomaly	CODA
Familial Coda

Suppurative Periapical Periodontitis

Periapical Abscess	Apical Abscess
Suppurative Apical Periodontitis	Dentoalveolar Abscess
Dental Abscess With Sinus	Dentoalveolar Abscess With Sinus
Dental Sinus	Periapical Abscess Fistula
Apical Tooth Abscess	Apex Abscess
Dental Abscess Nos	Infection Of Tooth Nos
Abscess Of Tooth	Dental Infection Nos

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08536	MMP19 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	MMP19	MGD	MGI:1927899
Rattus norvegicus	MMP19	RGD	RGD:1311376
Bos taurus	MMP19	VGNC	VGNC:31523
Felis catus	MMP19	VGNC	VGNC:68286
Canis familiaris	MMP19	VGNC	VGNC:43279
Macaca mulatta	MMP19	VGNC	VGNC:74896

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MMP19 - matrix metallopeptidase 19 Gene

关于 MMP19

功能概要

MMP19 基因产物(3)

MMP19 蛋白结构

重组 MMP19 蛋白

关联疾病

直系同源

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MMP19 - matrix metallopeptidase 19 Gene

关于 MMP19

功能概要

MMP19 基因产物(3)

MMP19 蛋白结构

重组 MMP19 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z