2. Gene
  3. ASTN1 - astrotactin 1 Gene

ASTN1 - astrotactin 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：星形趋化因子 1

种属: Homo sapiens

同用名: ASTN

基因 ID: 460 | 基因类型: protein coding

关于 ASTN1

Cytogenetic location: 1q25.2 Genomic coordinates (GRCh38): 1:176,857,321-177,164,712 (from NCBI)

This gene has 5 transcripts (splice variants), 215 orthologues and 1 paralogue. Biased expression in brain (RPKM 17.5), adrenal (RPKM 5.3) and 1 other tissue.

功能概要

Astrotactin 是一种神经元粘附分子，是神经胶质细胞在发育中的大脑皮层区域 (包括大脑、海马、小脑和嗅球) 引导有丝分裂后成神经细胞迁移所必需的分子 (Fink 等人，1995 年) 。[OMIM 提供，2009 年 6 月]

Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM, Jun 2009]

ASTN1 基因产物(4)

mRNA Protein Name
NM_001286164.2 NP_001273093.1 astrotactin-1 isoform 3 precursor
NM_001364856.2 NP_001351785.1 astrotactin-1 isoform 4 precursor
NM_004319.3 NP_004310.1 astrotactin-1 isoform 1 precursor
NM_207108.3 NP_996991.1 astrotactin-1 isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
31169361 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ASTN1 蛋白结构

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (652 - 699)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1294 a.a.
蛋白主名 其他名称

astrotactin-1

关联疾病

疾病名称 别名
Ritscher-Schinzel Syndrome 1

3c Syndrome

Craniocerebellocardiac Dysplasia

RTSC1

Dandy-Walker-Like Malformation With Atrioventricular Septal Defect

Dandy-Walker Like Malformation With Atrioventricular Septal Defect

Cranio-Cerebello-Cardiac Dysplasia

Dandy-Walker-Like Malformation With Asd

Ritscher Schinzel Syndrome

Ritscher-Schinzel Cranio-Cerebello-Cardiac Syndrome

Ritscher-Schinzel Syndrome

3c
Migraine, Familial Hemiplegic, 1

FHM1

Mhp1

Fhm

Familial Hemiplegic Migraine 1

Migraine, Familial Hemiplegic, 1, With Progressive Cerebellar Ataxia

Familial Hemiplegic Migraine1 With Progressive Cerebellar Ataxia

Migraine Familial Hemiplegic With Progressive Cerebellar Ataxia

Migraine, Hemiplegic, Familial, Type 1

Hemiplegic Migraine, Familial Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01112 ASTN1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ASTN1 VGNC VGNC:70167
Felis catus ASTN1 VGNC VGNC:68452
Canis familiaris ASTN1 VGNC VGNC:38194
Bos taurus ASTN1 VGNC VGNC:26227
Rattus norvegicus ASTN1 RGD RGD:727799
Mus musculus ASTN1 MGD MGI:1098567
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