2. Gene
  3. NMBR - neuromedin B receptor Gene

NMBR - neuromedin B receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经调节素 B 受体

种属: Homo sapiens

同用名: BB1; BB1R; BRS1; NMB-R

基因 ID: 4829 | 基因类型: protein coding

关于 NMBR

Cytogenetic location: 6q24.1 Genomic coordinates (GRCh38): 6:142,074,484-142,147,122 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 15 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码一个 7 跨膜 G 蛋白偶联受体，该受体结合神经调节肽 B，它是胃肠道上皮组织以及正常和肿瘤肺的生长因子和有丝分裂原。该受体可能在平滑肌收缩、神经元反应和细胞生长调节中发挥作用。该受体的拮抗剂在抑制肿瘤细胞生长方面具有潜在的治疗用途。该基因的多态性可能与精神分裂症的易感性有关。该基因的可变剪接导致多个转录变体。[RefSeq 提供，2016 年 4 月]

This gene encodes a 7-transmembrane G protein-coupled receptor that binds neuromedin B, which is a growth factor and mitogen for gastrointestinal epithelial tissue and for normal and neoplastic lung. This receptor may play a role in smooth muscle contraction, neuronal responses, and the regulation of cell growth. Antagonists of this receptor have a potential therapeutic use in inhibiting tumor cell growth. Polymorphisms in this gene may be associated with a susceptibility for schizophrenia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2016]

NMBR 基因产物(3)

mRNA Protein Name
NM_001324307.2 NP_001311236.1 neuromedin-B receptor isoform b precursor
NM_001324308.2 NP_001311237.1 neuromedin-B receptor isoform b precursor
NM_002511.4 NP_002502.2 neuromedin-B receptor isoform a
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in antiviral innate immune response IMP
IMP: 通过突变表型推断
31601264 GOA
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
31601264 GOA
involved in positive regulation of interferon-alpha production IMP
IMP: 通过突变表型推断
31601264 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NMBR 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 322)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

neuromedin-B receptor

bombesin receptor 1

关联疾病

疾病名称 别名
Breast Osteosarcoma

Osteogenic Sarcoma Of Breast

Breast Extraskeletal Osteosarcoma
Gastrinoma

Gastrin Cell Tumour

Gastrin Secreting Tumor

Malignant Gastrinoma

Gastrinoma, Malignant
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Intellectual Developmental Disorder, Autosomal Dominant 41

MRD41

Autosomal Dominant Non-Syndromic Intellectual Disability 41

Mental Retardation, Autosomal Dominant 41

Autosomal Dominant Intellectual Developmental Disorder 41

Autosomal Dominant Mental Retardation 41

Mental Retardation, Autosomal Dominant, Type 41
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116216 PD 168368 Antagonist ≥99.0% 否
HY-W404002 BR102910 Inhibitor 99.80% 否
HY-103277A BIM 23042 TFA Antagonist 96.20% 否
HY-P1423A BA 1 TFA Agonist 99.76% 否
HY-103277 BIM 23042 Antagonist / 否
HY-P1423 BA 1 Agonist / 否
HY-RS09369 NMBR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NMBR RGD RGD:3181
Canis familiaris NMBR VGNC VGNC:43855
Felis catus NMBR VGNC VGNC:68502
Bos taurus NMBR VGNC VGNC:32124
Mus musculus NMBR MGD MGI:1100525
Macaca mulatta NMBR VGNC VGNC:104416
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