NPR3 - natriuretic peptide receptor 3 Gene

中文名称：利钠肽受体 3

种属: Homo sapiens

同用名: NPRC; ANP-C; ANPRC; BOMOS; NPR-C; ANPR-C; GUCY2B; C5orf23

基因 ID: 4883 | 基因类型: protein coding

关于 NPR3

Cytogenetic location: 5p13.3 Genomic coordinates (GRCh38): 5:32,690,872-32,791,720 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in kidney (RPKM 35.4), fat (RPKM 14.2) and 8 other tissues.

功能概要

该基因编码三种利尿钠肽受体之一。利钠肽是调节血容量和压力、肺动脉高压和心脏功能以及一些代谢和生长过程的小肽。该基因的产物编码利钠肽受体，负责通过受体的内吞作用清除循环和细胞外利钠肽。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2011 年 2 月]

This gene encodes one of three natriuretic peptide receptors. Natriutetic Peptides are small Peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic Peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

NPR3 基因产物(6)

mRNA	Protein	Name
NM_000908.4	NP_000899.1	atrial natriuretic peptide receptor 3 isoform 2 precursor
NM_001204375.2	NP_001191304.1	atrial natriuretic peptide receptor 3 isoform 1 precursor
NM_001204376.2	NP_001191305.1	atrial natriuretic peptide receptor 3 isoform 3
NM_001363652.2	NP_001350581.1	atrial natriuretic peptide receptor 3 isoform 4
NM_001364458.2	NP_001351387.1	atrial natriuretic peptide receptor 3 isoform 5
NM_001364460.2	NP_001351389.1	atrial natriuretic peptide receptor 3 isoform 6

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chloride ion binding	IDA IDA: 通过直接分析推断	16870210	GOA
enables hormone binding	IPI IPI: 通过物理相互作用推断	16870210	GOA
enables natriuretic peptide receptor activity	IDA IDA: 通过直接分析推断	1660465	GOA
enables peptide binding	IPI IPI: 通过物理相互作用推断	16870210	GOA
enables peptide hormone binding	IPI IPI: 通过物理相互作用推断	1660465	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16870210	GOA
enables protein homodimerization activity	IDA IDA: 通过直接分析推断	16870210	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-containing complex	IDA IDA: 通过直接分析推断	16870210	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NPR3 蛋白结构

ANF_receptor

0
100
200
300
400
500
541 a.a.

蛋白主名

其他名称

atrial natriuretic peptide receptor 3

atrial natriuretic peptide clearance receptor

重组 NPR3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71122	NPR3 Protein, Human (HEK293, Fc)	P17342-1 (T24-E481)	≥95%

NPR3 抗体

目录号	产品名	应用	反应物种
HY-P81796	NPR3 Antibody (YA1541)	WB, FC	Human, Mouse, Rat

关联疾病

疾病名称

别名

Boudin-Mortier Syndrome

BOMOS

Tall Stature And Long Digits With Extra Epiphyses

Ischemic Colitis

Colitis, Ischemic

Irreversible Ischaemic Colitis

Anismus

Acromesomelic Dysplasia

Acromesomelic Dwarfism	Dysplasia, Acromesomelic
Acromesomelic Dysplasia Hunter-Thompson Type

Functional Diarrhea

Functional Diarrhoea

Acromesomelic Dysplasia 1

Acromesomelic Dysplasia, Maroteaux Type	Amdm
Acromesomelic Dysplasia 1, Maroteaux Type	AMD1
St. Helena Dysplasia	Acromesomelic Dysplasia-1
Acromesomelic Dysplasia Maroteaux Type	Acromesomelic Dwarfism Maroteux Type
Dysplasia, Acromesomelic, Type 1, Maroteaux	Acromesomelic Dysplasia Hunter-Thompson Type

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Hypertension, Pulmonary, Primary
Idiopathic Pulmonary Hypertension	Idiopathic Pulmonary Arterial Hypertension
Pulmonary Htn - [Hypertension]

Secretory Diarrhea

Pheochromocytoma

Pheochromocytoma, Susceptibility To	Phaeochromocytoma
Adrenal Gland Chromaffin Paraganglioma	Adrenal Gland Chromaffinoma
Adrenal Gland Paraganglioma	Adrenal Gland Pheochromocytoma
Chromaffin Paraganglioma Of The Adrenal Gland	Intraadrenal Paraganglioma
PCC	Chromaffin Cell Tumor
Medullary Chromaffinoma	Medullary Paraganglioma
Pheochromoblastoma	Pheochromocytomas
Chromaffin Cell Neoplasm	Pheochromocytoma, Malignant

Volvulus Of Midgut

Volvulus	Intestinal Volvulus
Intestinal Malrotation, Familial	Familial Intestinal Malrotation
Twist Of Intestine, Bowel, Or Colon

Constipation

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Body Mass Index Quantitative Trait Locus 11

OBESITY	Obesity, Susceptibility To
Leanness, Inherited	Obesity, Susceptibility To, Bmiq11
Obesity, Mild, Early-Onset	Obesity, Association With
Obesity, Early-Onset, Susceptibility To	Obesity, Severe
Obesity, Severe, And Type Ii Diabetes	Obesity, Late-Onset
Obesity , Susceptibility To	BMIQ11
Obesity Bmiq11	Obesity, Early-Onset
Simple Obesity Nos	Excess Fat
Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified	Adiposis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09499	NPR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	NPR3	MGD	MGI:97373
Rattus norvegicus	NPR3	RGD	RGD:3196
Canis familiaris	NPR3	VGNC	VGNC:58320
Macaca mulatta	NPR3	VGNC	VGNC:75390
Felis catus	NPR3	VGNC	VGNC:68535
Others	NPR3	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NPR3 - natriuretic peptide receptor 3 Gene

关于 NPR3

功能概要

NPR3 基因产物(6)

NPR3 蛋白结构

重组 NPR3 蛋白

NPR3 抗体

关联疾病

直系同源

热门区域

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NPR3 - natriuretic peptide receptor 3 Gene

关于 NPR3

功能概要

NPR3 基因产物(6)

NPR3 蛋白结构

重组 NPR3 蛋白

NPR3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z