1. Gene
  2. Lpar2 - lysophosphatidic acid receptor 2 Gene

Lpar2 - lysophosphatidic acid receptor 2 Gene

中文名称:溶血磷脂酸受体 2

种属: Rattus norvegicus

同用名: Edg4; RGD1561336

基因 ID: 498609 | 基因类型: protein coding

关于 Lpar2

Primary_assembly 16: 19,595,655-19,599,998 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 270 orthologues and 18 paralogues. Biased expression in Adrenal (RPKM 44.7), Kidney (RPKM 38.9) and 6 other tissues.

功能概要

预测该基因编码的蛋白可启动 G 蛋白偶联受体活性和 PDZ 结构域结合活性。预计参与腺苷酸环化酶激活 G 蛋白偶联受体信号通路和代谢过程的调控。预计作用于 G 蛋白偶联受体信号通路的上游或内部; MAPK 级联的正调控;和 Rho 蛋白信号转导的正调控。预测位于细胞表面。预计在细胞质中有活性;谷氨酸能突触;和质膜。预计是突触前活动区膜的组成部分。预测与内吞囊泡共定位。与人类 LPAR2(溶血磷脂酸受体 2)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled receptor activity and PDZ domain binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Predicted to be located in cell surface. Predicted to be active in cytoplasm; glutamatergic synapse; and plasma membrane. Predicted to be integral component of presynaptic active zone membrane. Predicted to colocalize with endocytic vesicle. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Lpar2 基因产物(1)

mRNA Protein Name
NM_001109109.2 NP_001102579.2 lysophosphatidic acid receptor 2

Lpar2 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (29 - 302)

7tm_GPCRs

7tm_GPCRs: cd14964 (31 - 55)

7tm_GPCRs

7tm_GPCRs: cd14964 (64 - 85)

7tm_GPCRs

7tm_GPCRs: cd14964 (101 - 123)

7tm_GPCRs

7tm_GPCRs: cd14964 (145 - 161)

7tm_GPCRs

7tm_GPCRs: cd14964 (182 - 205)

7tm_GPCRs

7tm_GPCRs: cd14964 (236 - 258)

7tm_GPCRs

7tm_GPCRs: cd14964 (270 - 295)

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  • 348 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 2

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4

pre-B-cell leukemia transcription factor 4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lpar2 NCBI NCBI:9170