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  2. LPAR2 - lysophosphatidic acid receptor 2 Gene

LPAR2 - lysophosphatidic acid receptor 2 Gene

中文名称:溶血磷脂酸受体 2

种属: Homo sapiens

同用名: EDG4; LPA2; EDG-4; LPA-2

基因 ID: 9170 | 基因类型: protein coding

关于 LPAR2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,623,655-19,628,529 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 18 paralogues. Broad expression in testis (RPKM 11.9), bone marrow (RPKM 11.1) and 22 other tissues.

功能概要

该基因编码 G 蛋白偶联受体家族 I 的成员,以及 EDG 蛋白家族。这种蛋白质作为溶血磷脂酸 (LPA) 受体发挥作用,并通过与 Gi 和 Gq 蛋白结合,促进 Ca2+ 动员,这是细胞中对 LPA 的关键细胞反应。已经描述了另一种剪接变体,但尚未确定其全长序列。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

LPAR2 基因产物(7)

mRNA Protein Name
NM_001395660.1 NP_001382589.1 lysophosphatidic acid receptor 2
XM_017027469.2 XP_016882958.1 lysophosphatidic acid receptor 2 isoform X1
NM_004720.7
XM_024451774.2 XP_024307542.1 lysophosphatidic acid receptor 2 isoform X1
XM_047439678.1 XP_047295634.1 lysophosphatidic acid receptor 2 isoform X1
XM_017027468.3 XP_016882957.1 lysophosphatidic acid receptor 2 isoform X1
XM_047439679.1 XP_047295635.1 lysophosphatidic acid receptor 2 isoform X1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
14688263 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
19306925 GOA
colocalizes with endocytic vesicle IDA
IDA: 通过直接分析推断
19306925 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LPAR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 295)

  • 0
  • 100
  • 200
  • 300
  • 351 a.a.
蛋白主名 其他名称

lysophosphatidic acid receptor 2

G protein-coupled receptor

LPA receptor 2

LPA receptor EDG4

endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4

lysophosphatidic acid receptor EDG4

lysophosphatidic acid receptor Edg-4

LPAR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra LPAR2 Q9HBW0 NHERF2 Homo sapiens Q15599
Pull Down
16203867
Intra LPAR2 Q9HBW0 LGALS3 Homo sapiens P17931
Anti Tag CoIP
28514442
Intra LPAR2 Q9HBW0 LGALS3 Homo sapiens P17931
Anti Tag CoIP
33961781
Intra LPAR2 Q9HBW0 CFTR Homo sapiens P13569
Crosslink
16203867
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Secretory Diarrhea
Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Bos taurus LPAR2 VGNC VGNC:30956
Felis catus LPAR2 VGNC VGNC:63262
Mus musculus LPAR2 MGD MGI:1858422
Rattus norvegicus LPAR2 RGD RGD:1561336
Canis familiaris LPAR2 VGNC VGNC:42743
Macaca mulatta LPAR2 VGNC VGNC:74409