NHERF2 - NHERF family PDZ scaffold protein 2 Gene

中文名称：NHERF 家族 PDZ 支架蛋白 2

种属: Homo sapiens

同用名: SIP1; OCTS2; SIP-1; TKA-1; E3KARP; NHE3RF2; NHERF-2; SLC9A3R2

关于 NHERF2

功能概要

该基因编码 PDZ 支架蛋白的 NHERF 家族成员。这些蛋白质通过结合并调节膜受体和转运蛋白的膜表达和蛋白质-蛋白质相互作用来介导许多细胞过程。编码的蛋白质通过调节钠/氢交换器 3 的活性在肠道钠吸收中发挥作用，还可以调节囊性纤维化跨膜调节剂 (CFTR) 离子通道。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 11 月]

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]