CHST11 - carbohydrate sulfotransferase 11 Gene

中文名称：碳水化合物磺基转移酶 11

种属: Homo sapiens

同用名: C4ST; C4ST1; OCBMD; C4ST-1; HSA269537

基因 ID: 50515 | 基因类型: protein coding

关于 CHST11

Cytogenetic location: 12q23.3 Genomic coordinates (GRCh38): 12:104,456,948-104,762,014 (from NCBI)

This gene has 6 transcripts (splice variants), 197 orthologues, 6 paralogues and is associated with 63 phenotypes. Ubiquitous expression in appendix (RPKM 8.6), brain (RPKM 8.5) and 23 other tissues.

功能概要

该基因编码的蛋白质属于磺基转移酶 2 家族。它定位于高尔基体膜，催化硫酸盐转移到软骨素的 N-乙酰半乳糖胺 (GalNAc) 残基的 4 位。硫酸软骨素构成软骨中存在的主要蛋白多糖，分布在许多细胞和细胞外基质的表面。据报道，一名 B 细胞慢性淋巴细胞白血病患者发生了涉及该基因和 IgH、t (12;14) (q23;q32) 的染色体易位。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is localized to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving this gene and IgH, t(12;14)(q23;q32), has been reported in a patient with B-cell chronic lymphocytic leukemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

CHST11 基因产物(2)

mRNA	Protein	Name
NM_001173982.2	NP_001167453.1	carbohydrate sulfotransferase 11 isoform 2
NM_018413.6	NP_060883.1	carbohydrate sulfotransferase 11 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables N-acetylgalactosamine 4-O-sulfotransferase activity	IDA IDA: 通过直接分析推断	11056388	GOA
enables chondroitin 4-sulfotransferase activity	IDA IDA: 通过直接分析推断	11056388	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in chondroitin sulfate biosynthetic process	IDA IDA: 通过直接分析推断	11056388	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHST11 蛋白结构

Sulfotransfer_2

0
100
200
300
352 a.a.

蛋白主名

其他名称

carbohydrate sulfotransferase 11

C4S-1

重组 CHST11 蛋白

目录号	产品名	蛋白编号	纯度
HY-P76257	CHST11 Protein, Human (sf9, His)	Q9NPF2-2 (M36-E347)	≥95%

关联疾病

疾病名称

别名

Osteochondrodysplasia, Brachydactyly, And Overlapping Malformed Digits

OCBMD

Mucinoses

Brachydactyly

Costello Syndrome

Faciocutaneoskeletal Syndrome	Fcs Syndrome
Congenital Myopathy With Excess Of Muscle Spindles	CSTLO
CMEMS	Fcss
Myopathy, Congenital, With Excess Of Muscle Spindles

Progressive Pseudorheumatoid Dysplasia

Progressive Pseudorheumatoid Arthropathy Of Childhood	Arthropathy, Progressive Pseudorheumatoid, Of Childhood
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy	Ppd
Ppac	Sedt-Pa
Spondyloepiphyseal Dysplasia Tarda-Progressive Arthropathy Syndrome	PPRD
Progressive Pseudorheumatoid Chondrodysplasia	Spondyloepiphyseal Dysplasia Tarda - Progressive Arthropathy
Spondyloepiphyseal Dysplasia Tarda With Progressive Arthropathy
Dysplasia, Pseudorheumatoid, Progressive

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Spondyloepiphyseal Dysplasia With Congenital Joint Dislocations

Spondyloepiphyseal Dysplasia	Chst3-Related Skeletal Dysplasia
Humerospinal Dysostosis	Spondyloepiphyseal Dysplasia, Omani Type
Chondrodysplasia With Multiple Dislocations	SEDCJD
Hsd	Cdmd
Humero-Spinal Dysostosis	Kozlowski Celermajer Tink Syndrome
Chondrodysplasia With Congenital Joint Dislocations, Chst3 Type	Larsen Syndrome, Recessive Type
Humero-Spinal Dysostosis With Congenital Heart Disease	Omani Type
Sed	Chst3 Deficiency
Chst3-Related Dysplasia	Recessive Larsen Syndrome
Autosomal Recessive Larsen Syndrome	Sed With Luxations, Chst3 Type
Sed, Omani Type	Sdcd, Chst3 Type
Spondyloepiphyseal Dysplasia With Congenital Joint Dyslocations, Chst3 Type	Sed Omani Type
Spondyloepiphyseal Dysplasia Omani Type	Larsen Syndrome, Autosomal Recessive
Mucopolysaccharidosis Iv	Spondyloepiphyseal Dysplasia, Congenita

Scoliosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02683	CHST11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CHST11	RGD	RGD:1308400
Canis familiaris	CHST11	VGNC	VGNC:39251
Felis catus	CHST11	VGNC	VGNC:83532
Mus musculus	CHST11	MGD	MGI:1927166
Bos taurus	CHST11	VGNC	VGNC:27339
Macaca mulatta	CHST11	VGNC	VGNC:82123
Others	CHST11	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CHST11 - carbohydrate sulfotransferase 11 Gene

关于 CHST11

功能概要

CHST11 基因产物(2)

CHST11 蛋白结构

重组 CHST11 蛋白

关联疾病

直系同源

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CHST11 - carbohydrate sulfotransferase 11 Gene

关于 CHST11

功能概要

CHST11 基因产物(2)

CHST11 蛋白结构

重组 CHST11 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z