Ednrb - endothelin receptor type B Gene

中文名称：B 型内皮素受体

种属: Rattus norvegicus

同用名: Etb; Ednra

关于 Ednrb

功能概要

该基因编码的蛋白可启动内皮素受体活性和 1 型血管紧张素受体结合活性。参与多个过程，包括维持血管直径；阴茎勃起的积极调节；和肾钠排泄的正调节。位于膜筏内；核膜;和质膜。用于研究多种疾病，包括动脉疾病（多种）；淋巴细胞减少症;巨结肠（多个）；门静脉高压症;和 2 型糖尿病。哮喘的生物标志物；肝肺综合征;和高血压。该基因的人类直系同源物与 ABCD 综合征有关；先天性巨结肠症； Waardenburg 综合征 4A 型；瓦登伯格综合症；和哮喘。与人 EDNRB（B 型内皮素受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Endothelin Receptor activity and type 1 Angiotensin Receptor binding activity. Involved in several processes, including blood vessel diameter maintenance; positive regulation of penile erection; and positive regulation of renal sodium excretion. Located in membrane raft; nuclear membrane; and plasma membrane. Used to study several diseases, including artery disease (multiple); lymphopenia; megacolon (multiple); portal hypertension; and type 2 diabetes mellitus. Biomarker of asthma; hepatopulmonary syndrome; and hypertension. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg syndrome type 4A; Waardenburg's syndrome; and asthma. Orthologous to human EDNRB (Endothelin Receptor type B). [provided by Alliance of Genome Resources, Apr 2022]