Chek2 - checkpoint kinase 2 Gene

中文名称：检查点激酶 2

种属: Mus musculus

同用名: CHK2; Cds1; Rad53; HUCDS1

关于 Chek2

功能概要

该基因编码的蛋白可启动蛋白激酶活性。作用于细胞对伽马辐射的反应上游或内部；肽基丝氨酸磷酸化；和 p53 类介质的信号转导。预测位于高尔基体和PML体。预计在细胞质和细胞核中有活性。预测与染色体、端粒区域共定位。以多种结构表达，包括中枢神经系统；泌尿生殖系统；和肝脏。该基因的人类直系同源物与多种疾病有关，包括 Li-Fraumeni 综合征 2；乳腺癌（多发性）；结直肠癌；骨肉瘤;和前列腺癌。与人类 CHEK2（检查点激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase activity. Acts upstream of or within cellular response to gamma radiation; peptidyl-serine phosphorylation; and signal transduction by p53 class mediator. Predicted to be located in Golgi apparatus and PML body. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromosome, telomeric region. Is expressed in several structures, including central nervous system; genitourinary system; and liver. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome 2; breast Cancer (multiple); colorectal cancer; osteosarcoma; and prostate Cancer. Orthologous to human CHEK2 (checkpoint kinase 2). [provided by Alliance of Genome Resources, Apr 2022]