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  3. Mink1 - misshapen-like kinase 1 (zebrafish) Gene

Mink1 - misshapen-like kinase 1 (zebrafish) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：畸形样激酶 1 (斑马鱼)

种属: Mus musculus

同用名: B55; MINK; Ysk2; Map4k6

基因 ID: 50932 | 基因类型: protein coding

关于 Mink1

Chromosome 11: 70,453,707-70,505,309 forward strand.GRCm39:CM001004.3

This gene has 13 transcripts (splice variants), 204 orthologues, 35 paralogues and is associated with 19 phenotypes. Ubiquitous expression in cortex adult (RPKM 44.5), frontal lobe adult (RPKM 42.1) and 28 other tissues.

功能概要

该基因编码的蛋白可启动 ATP 结合活性和蛋白丝氨酸/苏氨酸激酶活性。参与 JNK 级联的正向调控； p38MAPK 级联的正调控；和蛋白质磷酸化。在阴性胸腺 T 细胞选择的上游或内部起作用。预测位于高尔基体。预计在细胞质中有活性。与人类 MINK1 同源（畸形像激酶 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in positive regulation of JNK cascade; positive regulation of p38MAPK cascade; and protein phosphorylation. Acts upstream of or within negative thymic T cell selection. Predicted to be located in Golgi apparatus. Predicted to be active in cytoplasm. Orthologous to human MINK1 (misshapen like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Mink1 基因产物(7)

mRNA Protein Name
NM_001403557.1 NP_001390486.1 misshapen-like kinase 1 isoform 7
NM_001403556.1 NP_001390485.1 misshapen-like kinase 1 isoform 6
NM_001403555.1 NP_001390484.1 misshapen-like kinase 1 isoform 5
NM_001045959.2 NP_001039424.1 misshapen-like kinase 1 isoform 3
NM_016713.3 NP_057922.2 misshapen-like kinase 1 isoform 1
NM_001045964.2 NP_001039429.1 misshapen-like kinase 1 isoform 4
NM_176893.3 NP_795712.2 misshapen-like kinase 1 isoform 2

Mink1 蛋白结构

STKc_MAP4K4_6_N

STKc_MAP4K4_6_N: cd06636 (7 - 288)

CNH

CNH: smart00036 (981 - 1279)

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  • 1300 a.a.
蛋白主名 其他名称

misshapen-like kinase 1

GCK family kinase MiNK

MAPK/ERK kinase kinase kinase 6

MEK kinase kinase 6

MEKKK 6

Misshapen/NIKs-related kinase

Yeast Sps1/Ste20-related kinase 2

misshapen/NIK-related kinase

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17437A Mefloquine hydrochloride 99.99% 是
HY-17437 Mefloquine 99.96% 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-108591 L-364,373 Activator 99.67% 否
HY-RS08454 MINK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08455 Mink1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08456 Mink1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mink1 NCBI NCBI:50488
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