2. Gene
  3. MINK1 - misshapen like kinase 1 Gene

MINK1 - misshapen like kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：畸形样激酶 1

种属: Homo sapiens

同用名: B55; ZC3; MINK; YSK2; MAP4K6

基因 ID: 50488 | 基因类型: protein coding

关于 MINK1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,833,340-4,898,061 (from NCBI)

This gene has 14 transcripts (splice variants), 204 orthologues and 35 paralogues. Ubiquitous expression in skin (RPKM 48.7), brain (RPKM 31.3) and 25 other tissues.

功能概要

该基因编码属于生发中心激酶 (GCK) 家族的丝氨酸/苏氨酸激酶。该蛋白在结构上类似于与 NIK 相关的激酶，并且可能属于 GCK 家族中 NIK 相关激酶的一个独特亚家族。对小鼠同系物的研究表明，在出生后小鼠大脑发育过程中表达上调，cJun N 末端激酶 (JNK) 和 p38 通路激活。[RefSeq 提供，2016 年 3 月]

This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016]

MINK1 基因产物(29)

mRNA Protein Name
XM_047436173.1 XP_047292129.1 misshapen-like kinase 1 isoform X17
XM_006721532.2 XP_006721595.1 misshapen-like kinase 1 isoform X2
XM_017024706.1 XP_016880195.1 misshapen-like kinase 1 isoform X12
NM_170663.5 NP_733763.1 misshapen-like kinase 1 isoform 2
XM_006721536.2 XP_006721599.1 misshapen-like kinase 1 isoform X11
XM_047436175.1 XP_047292131.1 misshapen-like kinase 1 isoform X19
XM_017024704.1 XP_016880193.1 misshapen-like kinase 1 isoform X3
XM_047436179.1 XP_047292135.1 misshapen-like kinase 1 isoform X24
NM_153827.5 NP_722549.2 misshapen-like kinase 1 isoform 3
XM_011523906.1 XP_011522208.1 misshapen-like kinase 1 isoform X9
XM_047436174.1 XP_047292130.1 misshapen-like kinase 1 isoform X18
NM_001321236.2 NP_001308165.1 misshapen-like kinase 1 isoform 5
XM_017024705.1 XP_016880194.1 misshapen-like kinase 1 isoform X5
XM_047436170.1 XP_047292126.1 misshapen-like kinase 1 isoform X13
XM_047436178.1 XP_047292134.1 misshapen-like kinase 1 isoform X23
XM_047436169.1 XP_047292125.1 misshapen-like kinase 1 isoform X10
XM_047436168.1 XP_047292124.1 misshapen-like kinase 1 isoform X8
NM_015716.5 NP_056531.1 misshapen-like kinase 1 isoform 1
XM_017024707.3 XP_016880196.1 misshapen-like kinase 1 isoform X16
XM_047436171.1 XP_047292127.1 misshapen-like kinase 1 isoform X14
XM_047436167.1 XP_047292123.1 misshapen-like kinase 1 isoform X7
XM_047436172.1 XP_047292128.1 misshapen-like kinase 1 isoform X15
XM_047436176.1 XP_047292132.1 misshapen-like kinase 1 isoform X21
XM_047436177.1 XP_047292133.1 misshapen-like kinase 1 isoform X22
XM_017024708.2 XP_016880197.1 misshapen-like kinase 1 isoform X20
NM_001024937.4 NP_001020108.1 misshapen-like kinase 1 isoform 4
XM_047436165.1 XP_047292121.1 misshapen-like kinase 1 isoform X4
XM_006721531.2 XP_006721594.1 misshapen-like kinase 1 isoform X1
XM_047436166.1 XP_047292122.1 misshapen-like kinase 1 isoform X6
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15469942 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18930710 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
15469942 GOA
NOT involved in microvillus assembly IMP
IMP: 通过突变表型推断
22797597 GOA
involved in positive regulation of JNK cascade IMP
IMP: 通过突变表型推断
15469942 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
15469942 GOA
involved in protein phosphorylation IMP
IMP: 通过突变表型推断
21690388 GOA
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
15469942 GOA
involved in regulation of cell-cell adhesion IMP
IMP: 通过突变表型推断
15469942 GOA
involved in regulation of cell-matrix adhesion IMP
IMP: 通过突变表型推断
15469942 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
15469942 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
18930710 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MINK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (25 - 289)

CNH

CNH: CNH domain (1024 - 1302)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1332 a.a.
蛋白主名 其他名称

misshapen-like kinase 1

GCK family kinase MINK

MAPK/ERK kinase kinase kinase 6

MEK kinase kinase 6

MEKKK 6

misshapen/NIK-related kinase

mitogen-activated protein kinase kinase kinase kinase 6

MINK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Anti Tag CoIP
25852190
种属内
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Pull Down
32707033
种属内
MINK1 Q8N4C8 MAP4K4 Homo sapiens O95819
Anti Tag CoIP
33961781
种属内
MINK1 Q8N4C8 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
MINK1 Q8N4C8 RAP2A Homo sapiens P10114
Y2H
18930710
种属内
MINK1 Q8N4C8 HSF1 Homo sapiens Q00613
Pull Down
25816751
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Alzheimer Disease 15

AD15

Alzheimer'S Disease 15

Alzheimer Disease Without Neurofibrillary Tangles

Alzheimer'S Disease 15, Late Onset

Alzheimer'S Disease Without Neurofibrillary Tangles
Conjunctival Folliculosis

Acute Follicular Conjunctivitis
Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc
Long Qt Syndrome

Romano-Ward Syndrome

Long Q-T Syndrome

Lqt

Qt Syndrome, Long

Congenital Long Qt Syndrome

Familial Long Qt Syndrome
Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis

Conjunctivitis, Acute Hemorrhagic

Apollo Disease

Epidemic Hemorrhagic Conjunctivitis

Viral Conjunctiva Disorder

Viral Conjunctivitis Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17437A Mefloquine hydrochloride 99.99% 是
HY-17437 Mefloquine 99.96% 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-111754 DMX-5804 Inhibitor 99.83% 否
HY-108591 L-364,373 Activator 99.67% 否
HY-RS08454 MINK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08455 Mink1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08456 Mink1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta MINK1 VGNC VGNC:81475
Canis familiaris MINK1 VGNC VGNC:53424
Felis catus MINK1 VGNC VGNC:97509
Mus musculus MINK1 MGD MGI:1355329
Bos taurus MINK1 VGNC VGNC:31479
Rattus norvegicus MINK1 RGD RGD:1359135
Others MINK1 NCBI
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