2. Gene
  3. RAP2A - RAP2A, member of RAS oncogene family Gene

RAP2A - RAP2A, member of RAS oncogene family Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：RAP2A，RAS 致癌基因家族成员

种属: Homo sapiens

同用名: KREV; RAP2; K-REV; RbBP-30

基因 ID: 5911 | 基因类型: protein coding

关于 RAP2A

Cytogenetic location: 13q32.1 Genomic coordinates (GRCh38): 13:97,434,169-97,469,128 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 35 paralogues. Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues.

功能概要

启用 GTPase 活动；胍基核糖核苷酸结合活性；和镁离子结合活性。参与多个过程，包括肌动蛋白细胞骨架重组；微绒毛组装；和蛋白质自身磷酸化的正调节。在蛋白质定位的建立上游或内部起作用。位于质膜和循环核内体膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin Cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]

RAP2A 基因产物(1)

mRNA Protein Name
NM_021033.7 NP_066361.1 ras-related protein Rap-2a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GDP binding IMP
IMP: 通过突变表型推断
9312017 GOA
enables GTP binding IDA
IDA: 通过直接分析推断
22797597 GOA
enables GTP binding IMP
IMP: 通过突变表型推断
9312017 GOA
enables GTPase activity IDA
IDA: 通过直接分析推断
1900290 GOA
enables magnesium ion binding IMP
IMP: 通过突变表型推断
9312017 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
14966141 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
15342639 GOA
involved in cellular response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
22797597 GOA
NOT involved in establishment of epithelial cell apical/basal polarity IMP
IMP: 通过突变表型推断
22797597 GOA
acts upstream of or within establishment of protein localization IDA
IDA: 通过直接分析推断
19061864 GOA
involved in microvillus assembly IMP
IMP: 通过突变表型推断
22797597 GOA
involved in positive regulation of protein autophosphorylation IDA
IDA: 通过直接分析推断
15342639 GOA
involved in positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22797597 GOA
involved in protein localization IDA
IDA: 通过直接分析推断
15342639 GOA
involved in protein localization to plasma membrane IMP
IMP: 通过突变表型推断
22797597 GOA
involved in regulation of JNK cascade IDA
IDA: 通过直接分析推断
14966141 GOA
involved in regulation of dendrite morphogenesis IDA
IDA: 通过直接分析推断
20159449 GOA
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
IDA: 通过直接分析推断
15953419 GOA
involved in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
IMP: 通过突变表型推断
15953419 GOA
involved in regulation of synapse assembly IDA
IDA: 通过直接分析推断
30063210 GOA
involved in regulation of synapse assembly IMP
IMP: 通过突变表型推断
30063210 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
15953419 GOA
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
15953419 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
22797597 GOA
located in recycling endosome IDA
IDA: 通过直接分析推断
19061864 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
19061864 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RAP2A 蛋白结构

Ras

Ras: Ras family (5 - 164)

  • 0
  • 100
  • 183 a.a.
蛋白主名 其他名称

ras-related protein Rap-2a

RAP2, member of RAS oncogene family (K-rev)

RAP2A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAP2A P10114 RUNDC3A Homo sapiens Q59EK9-3
Y2H Array
32296183
种属内
RAP2A P10114 RUNDC3A Homo sapiens Q59EK9-3
Validated Y2H
32296183
种属内
RAP2A P10114 RUNDC3A Homo sapiens Q59EK9-3
Y2H Prey Pooling
32296183
种属内
RAP2A P10114 MINK1 Homo sapiens Q8N4C8
Anti Tag CoIP
33961781
种属内
RAP2A P10114 RGL1 Homo sapiens Q9NZL6-2
Y2H Array
32296183
种属内
RAP2A P10114 RGL1 Homo sapiens Q9NZL6-2
Y2H Prey Pooling
32296183
种属内
RAP2A P10114 RGL1 Homo sapiens Q9NZL6-2
Validated Y2H
32296183
种属内
RAP2A P10114 EMP3 Homo sapiens P54852
PLA
30614533
种属内
RAP2A P10114 EMP3 Homo sapiens P54852
BiFC
30614533
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cerebral Cavernous Malformations

Cerebral Cavernous Malformation

Cavernous Malformations Of Cns And Retina

Cerebral Cavernous Malformation 1

Cavernous Angiomatous Malformations

Cerebral Capillary Malformations

CCM

Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations

Familial Cavernous Angioma

Cavernous Angioma

Familial Cerebral Cavernous Malformation

Cerebral Cavernous Malformations 1

Cavernous Angioma, Familial

Cam

Cerebral Cavernous Malformations-1

Cavernoma

Central Nervous System Cavernous Hemangioma

Cerebral Cavernous Hemangioma

Familial Cavernous Hemangioma

Familial Cavernous Malformation

Familial Cerebral Cavernous Angioma

Intracerebral Cavernous Hemangioma

CCM1

Cavernous Hemangioma Of The Brain

Cerebral Cavernoma

Cerebral Cavernous Malformations, Type 1

Hemangioma, Cavernous, Central Nervous System

Hemangioma, Cavernous

Angioma, Cavernous
Sporadic Breast Cancer

Sporadic Breast Carcinoma
Cerebrocostomandibular Syndrome

Cerebro-Costo-Mandibular Syndrome

CCMS

Rib Gap Defects With Micrognathia

Ccm Syndrome
Cavernous Hemangioma

Hemangioma, Cavernous

Cavernoma

Cavernous Haemangioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11657 RAP2A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus RAP2A VGNC VGNC:33719
Mus musculus RAP2A MGD MGI:97855
Felis catus RAP2A VGNC VGNC:102303
Rattus norvegicus RAP2A RGD RGD:620590
Canis familiaris RAP2A VGNC VGNC:45344
Macaca mulatta RAP2A VGNC VGNC:106288
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z