PCK2 - phosphoenolpyruvate carboxykinase 2, mitochondrial Gene

中文名称：磷酸烯醇丙酮酸羧激酶 2，线粒体

种属: Homo sapiens

同用名: PEPCK; PEPCK2; PEPCK-M

基因 ID: 5106 | 基因类型: protein coding

关于 PCK2

Cytogenetic location: 14q11.2-q12 Genomic coordinates (GRCh38): 14:24,094,171-24,104,125 (from NCBI)

This gene has 16 transcripts (splice variants), 1 gene allele, 201 orthologues, 1 paralogue and is associated with 2 phenotypes. Biased expression in duodenum (RPKM 127.7), small intestine (RPKM 91.2) and 8 other tissues.

功能概要

该基因编码一种线粒体酶，该酶在三磷酸鸟苷 (GTP) 存在的情况下催化草酰乙酸转化为磷酸烯醇丙酮酸。这种蛋白质的胞质形式由不同的基因编码，是肝脏糖异生的关键酶。已经描述了选择性剪接的转录物变体。[RefSeq 提供，2014 年 4 月]

This gene encodes a mitochondrial Enzyme that catalyzes the conversion of oxaloacetate to phosphoenolpyruvate in the presence of guanosine triphosphate (GTP). A cytosolic form of this protein is encoded by a different gene and is the key Enzyme of gluconeogenesis in the liver. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2014]

PCK2 基因产物(4)

mRNA	Protein	Name
NM_001018073.3	NP_001018083.2	phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform 2 precursor
NM_001291556.2	NP_001278485.1	phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform 3
NM_001308054.2	NP_001294983.1	phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform 3
NM_004563.4	NP_004554.3	phosphoenolpyruvate carboxykinase [GTP], mitochondrial isoform 1 precursor

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables manganese ion binding	IDA IDA: 通过直接分析推断	28955899	GOA
enables phosphoenolpyruvate carboxykinase (GTP) activity	EXP EXP: 通过实验结果推断	9657976	GOA
enables phosphoenolpyruvate carboxykinase (GTP) activity	IDA IDA: 通过直接分析推断	28955899	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21988832	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in mitochondrion	IDA IDA: 通过直接分析推断	8645161	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PCK2 蛋白结构

PEPCK_C

0
100
200
300
400
500
600
640 a.a.

蛋白主名

其他名称

phosphoenolpyruvate carboxykinase [GTP], mitochondrial

PEP carboxykinase

PCK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	PCK2	Q16822	SMAD3	Homo sapiens	P84022	Y2H	21988832
种属内	PCK2	Q16822	SMAD3	Homo sapiens	P84022	Anti Tag CoIP	21988832

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PCK2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75957	PCK2 Protein, Human (sf9, His-GST)	Q16822-1/NP_004554.3 (L33-M640)	≥95%

PCK2 抗体

目录号	产品名	应用	反应物种
HY-P81802	PCK2 Antibody (YA1547)	WB, IHC-F, IHC-P, ICC/IF	Human, Mouse, Rat

关联疾病

疾病名称

别名

Phosphoenolpyruvate Carboxykinase Deficiency, Mitochondrial

Pck2 Deficiency	Phosphoenolpyruvate Carboxykinase 2 Deficiency
PCKDM	Pepck2 Deficiency
Pepck Deficiency, Mitochondrial	Pepck 2 Deficiency
Pepck2	Mitochondrial Phosphoenolpyruvate Carboxykinase Deficiency
M-PEPCKD

Pepck 1 Deficiency

Phosphoenolpyruvate Carboxykinase Deficiency	Phosphoenolpyruvate Carboxykinase Deficiency
Pep Carboxykinase Deficiency	Phosphoenolpyruvate Carboxykinase-1 Deficiency
Phosphoenolpyruvate Carboxylase Deficiency	Phosphopyruvate Carboxylase Deficiency
Pepck Deficiency

Hypoglycemia

Hypoglycaemia	Low Blood Sugar
Hypoglycaemia Nos	Spontaneous Hypoglycaemia
Nondiabetic Hypoglycaemia	Hypoglycaemic Disorder Nos
Hypoglycaemic Syndrome

Glucose Intolerance

Glucose: Intolerance	Glucose: Malabsorption
Malabsorption Of Glucose	Impaired Glucose Tolerance

Hyperglycemia

Type 2 Diabetes Mellitus

Insulin Resistance	NIDDM
Type 2 Diabetes	Diabetes Mellitus, Non-Insulin-Dependent
T2D	Noninsulin-Dependent Diabetes Mellitus
Diabetes Mellitus, Type Ii	Maturity-Onset Diabetes
Insulin Resistance, Severe, Digenic	Diabetes Mellitus, Type 2
Diabetes Mellitus, Noninsulin-Dependent	Diabetes Mellitus, Noninsulin-Dependent, Association With
Diabetes Mellitus, Noninsulin-Dependent, Late Onset	Hypertension, Insulin Resistance-Related, Susceptibility To
Insulin Resistance, Susceptibility To	Non-Insulin-Dependent Diabetes Mellitus
Type Ii Diabetes Mellitus	Adult-Onset Diabetes Mellitus
Maturity-Onset Diabetes Mellitus	Diabetes Mellitus Type 2
Type Ii Diabetes	Type 2 Diabetes Mellitus, Susceptibility To
Diabetes, Type 2	Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To
Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 2, Susceptibility To
Diabetes Mellitus, Noninsulin-Dependent, 2	Diabetes Mellitus, Type Ii, Susceptibility To
Hypertension, Insulin Resistance-Related	Adult-Onset Diabetes
Aodm	Diabetes Mellitus, Adult-Onset
Diabetes Mellitus Type Ii	Diabetes Mellitus Type 2, Susceptibility To
Diabetes, Type Ii, Susceptibility To	Diabetes Type 2
Diabetes Mellitus	Adult Onset Diabetes
Maturity Onset Diabetes	Nonketotic Diabetes
Non-Insulin Dependent Diabetes Mellitus	T2dm - [Type 2 Diabetes Mellitus]
Niddm - [Non Insulin Dependent Diabetes Mellitus]	Dm2
Dm Type Ii	Diabetic Type 2
Insulin Requiring Type 2 Diabetes	Noninsulin Dependent Diabetes
Non-Insulin-Dependent Diabetes Mellitus Without Complications	Diabetes Due To Insulin Secretory Defect
Diabetes Mellitus Due To Insulin Secretory Defect	Non-Insulin-Dependent Diabetes Of The Young
Senile Diabetes	Nonketotic Hyperglycaemia
Stable Diabetes

Maturity-Onset Diabetes Of The Young

MODY	Maturity Onset Diabetes Mellitus In Young
Mason-Type Diabetes	Mason Type Diabetes
Maturity Onset Diabetes Of The Young	Mody Syndrome
Diabetes Of The Young, Maturity-Onset

Acute Porphyria

Porphyrias, Hepatic	Hepatic Porphyria
Porphyria Hepatic	Acute Intermittent Porphyria

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Diabetes Mellitus

Diabetes

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS16227	Pck2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS10153	PCK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS16227A	Pck2 Mouse Pre-designed siRNA Set A-1	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PCK2	VGNC	VGNC:68727
Rattus norvegicus	PCK2	RGD	RGD:1311112
Canis familiaris	PCK2	VGNC	VGNC:44308
Macaca mulatta	PCK2	VGNC	VGNC:75780
Bos taurus	PCK2	VGNC	VGNC:32632
Mus musculus	PCK2	MGD	MGI:1860456
Others	PCK2	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PCK2 - phosphoenolpyruvate carboxykinase 2, mitochondrial Gene

关于 PCK2

功能概要

PCK2 基因产物(4)

PCK2 蛋白结构

PCK2 蛋白互作信息

重组 PCK2 蛋白

PCK2 抗体

关联疾病

直系同源

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PCK2 - phosphoenolpyruvate carboxykinase 2, mitochondrial Gene

关于 PCK2

功能概要

PCK2 基因产物(4)

PCK2 蛋白结构

PCK2 蛋白互作信息

重组 PCK2 蛋白

PCK2 抗体

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

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