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  3. SERPINA10 - serpin family A member 10 Gene

SERPINA10 - serpin family A member 10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：serpin 家族成员 10

种属: Homo sapiens

同用名: PZI; ZPI

基因 ID: 51156 | 基因类型: protein coding

关于 SERPINA10

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,280,460-94,293,268 (from NCBI)

This gene has 4 transcripts (splice variants), 1 gene allele, 256 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 44.6).

功能概要

该基因编码的蛋白质属于 serpin 家族。它主要在肝脏中表达并在血浆中分泌。它在蛋白质 Z、钙和磷脂存在下抑制凝血因子 Xa 和 XIa 的活性。该基因的突变与静脉血栓形成有关。已发现该基因的可变剪接转录本变体。[RefSeq 提供，2010 年 5 月]

The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]

SERPINA10 基因产物(2)

mRNA Protein Name
NM_001100607.3 NP_001094077.1 protein Z-dependent protease inhibitor precursor
NM_016186.3 NP_057270.1 protein Z-dependent protease inhibitor precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20427285 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in regulation of acrosome reaction IDA
IDA: 通过直接分析推断
11751269 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINA10 蛋白结构

Serpin

Serpin: Serpin (serine protease inhibitor) (79 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 444 a.a.
蛋白主名 其他名称

protein Z-dependent protease inhibitor

PZ-dependent protease inhibitor

重组 SERPINA10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71292 Serpin A10 Protein, Human (HEK293, His) Q9UK55 (L22-L444) ≥95%

关联疾病

疾病名称 别名
Thrombosis

Thrombosis Of Blood Vessel
Protein Z Deficiency
Thrombophilia

Hypercoagulability State
Shwartzman Phenomenon

Shwartzman Reaction
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12697 SERPINA10 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SERPINA10 RGD RGD:621220
Mus musculus SERPINA10 MGD MGI:2667725
Macaca mulatta SERPINA10 VGNC VGNC:77242
Bos taurus SERPINA10 VGNC VGNC:34465
Others SERPINA10 NCBI
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