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  3. DBR1 - debranching RNA lariats 1 Gene

DBR1 - debranching RNA lariats 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脱支 RNA 套索 1

种属: Homo sapiens

基因 ID: 51163 | 基因类型: protein coding

关于 DBR1

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:138,160,988-138,174,921 (from NCBI)

This gene has 10 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in stomach (RPKM 5.7), bone marrow (RPKM 5.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种 RNA 套索脱支酶，可水解 2'-5' 主要支链磷酸二酯键。编码的蛋白质专门针对切除的套索内含子 RNA 分支点处的键，将它们转化为线性分子，然后被降解。这种蛋白质也可能参与逆转录病毒复制。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is an RNA lariat debranching Enzyme that hydrolyzes 2'-5' prime branched phosphodiester bonds. The encoded protein specifically targets the bonds at the branch point of excised lariat intron RNA, converting them to linear molecules that are then degraded. This protein may also be involved in retroviral replication. [provided by RefSeq, Nov 2011]

DBR1 基因产物(1)

mRNA Protein Name
NM_016216.4 NP_057300.2 lariat debranching enzyme
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA lariat debranching enzyme activity IMP
IMP: 通过突变表型推断
10982890 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA fragment catabolic process IMP
IMP: 通过突变表型推断
37656279 GOA
involved in RNA splicing, via transesterification reactions IMP
IMP: 通过突变表型推断
10982890 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
10982890 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DBR1 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (1 - 229)

DBR1

DBR1: Lariat debranching enzyme, C-terminal domain (243 - 377)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 544 a.a.
蛋白主名 其他名称

lariat debranching enzyme

RNA lariat debranching enzyme

关联疾病

疾病名称 别名
Encephalitis, Acute, Infection -Induced 11

IIAE11

Encephalitis, Acute, Infection -Induced, Susceptibility To, 11

Encephalitis, Acute, Infection -Induced, 11
Viral Encephalitis

Epidemic Encephalitis

Encephalitis Viral

Encephalitis, Arbovirus

Arbovirus Encephalitis

Postviral Encephalitis Nos

Equine Encephalitis

Tick-Borne Encephalitis

Viral Encephalitis Transmitted By Tick

Mosquito-Borne Encephalitis

Acute Haemorrhagic Encephalitis

Acute Idiopathic Encephalitis

Chronic Viral Encephalitis

Endemic Encephalitis

Subacute Viral Encephalitis

Viral Haemorrhagic Encephalitis

Viral Nonepidemic Encephalitis

Nonepidemic Encephalitis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-156744 DBr-1 Degrader / 否
HY-RS03553 DBR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus DBR1 VGNC VGNC:61350
Macaca mulatta DBR1 VGNC VGNC:71626
Rattus norvegicus DBR1 RGD RGD:1598038
Bos taurus DBR1 VGNC VGNC:27895
Canis familiaris DBR1 VGNC VGNC:39786
Mus musculus DBR1 MGD MGI:1931520
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