2. Gene
  3. ANGPT4 - angiopoietin 4 Gene

ANGPT4 - angiopoietin 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：血管生成素 4

种属: Homo sapiens

同用名: ANG3; ANG4

基因 ID: 51378 | 基因类型: protein coding

关于 ANGPT4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:869,900-916,334 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 25 paralogues. Biased expression in fat (RPKM 1.7), ovary (RPKM 1.2) and 11 other tissues.

功能概要

血管生成素是在血管发育和血管生成中具有重要作用的蛋白质。所有血管生成素都以相似的亲和力与内皮细胞特异性酪氨酸蛋白激酶受体结合。它们促进血管生成的机制被认为涉及调节内皮细胞与支持性血管周围细胞的相互作用。由该基因编码的蛋白质起着激动剂的作用，是一种血管生成素。[RefSeq 提供，2008 年 7 月]

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All Angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

ANGPT4 基因产物(2)

mRNA Protein Name
NM_001322809.2 NP_001309738.1 angiopoietin-4 isoform 2 precursor
NM_015985.4 NP_057069.1 angiopoietin-4 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables receptor tyrosine kinase binding IDA
IDA: 通过直接分析推断
10051567 GOA
enables transmembrane receptor protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
10051567 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
12958144 GOA
NOT involved in endothelial cell proliferation IDA
IDA: 通过直接分析推断
10025962 GOA
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
16790085 GOA
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12958144 GOA
involved in negative regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
16790085 GOA
involved in positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
15284220 GOA
involved in positive regulation of blood vessel endothelial cell migration IDA
IDA: 通过直接分析推断
15284220 GOA
involved in positive regulation of endothelial cell migration IDA
IDA: 通过直接分析推断
12958144 GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
15851516 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
10025962 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANGPT4 蛋白结构

Fibrinogen_C

Fibrinogen_C: Fibrinogen beta and gamma chains, C-terminal globular domain (289 - 500)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
蛋白主名 其他名称

angiopoietin-4

重组 ANGPT4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74411 Angiopoietin-4 Protein, Human (HEK293, Fc) Q9Y264-1 (M282-I503) ≥95%

关联疾病

疾病名称 别名
Angiosarcoma

Hemangiosarcoma
Glaucoma 3, Primary Congenital, A

Buphthalmos

Glaucoma, Congenital

Congenital Glaucoma

Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, Or Adult Onset

GLC3A

Glc3

Buphthalmia

Primary Congenital Glaucoma

Glaucoma, Primary Open Angle, Juvenile-Onset

Simple Buphthalmos

Buphthalmus

Glaucoma, Primary Open Angle, Adult-Onset

Primary Congenital Glaucoma 3a

Primary Infantile Glaucoma Type 3a

Glaucoma 3a, Primary Congenital

Glaucoma, Congenital, Primary, Type 3a

Hydrophthalmos

Cystic Eyeball
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00689 ANGPT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ANGPT4 VGNC VGNC:37856
Bos taurus ANGPT4 VGNC VGNC:25889
Macaca mulatta ANGPT4 VGNC VGNC:69812
Rattus norvegicus ANGPT4 RGD RGD:1307539
Felis catus ANGPT4 VGNC VGNC:67557
Mus musculus ANGPT4 MGD MGI:1336887
Others ANGPT4 NCBI
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