2. Gene
  3. TRPV2 - transient receptor potential cation channel subfamily V member 2 Gene

TRPV2 - transient receptor potential cation channel subfamily V member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：瞬时受体电位阳离子通道亚家族 V 成员 2

种属: Homo sapiens

同用名: VRL; VRL1; VRL-1

基因 ID: 51393 | 基因类型: protein coding

关于 TRPV2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,415,571-16,437,003 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 5 paralogues. Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues.

功能概要

该基因编码的离子通道可在 52 摄氏度以上的高温下激活。该蛋白可能参与感觉神经节中高温热反应的转导。据认为，在其他组织中，该通道可能会被热以外的刺激激活。[RefSeq 提供，2008 年 7 月]

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in Other tissues the channel may be activated by stimuli Other than heat. [provided by RefSeq, Jul 2008]

TRPV2 基因产物(1)

mRNA Protein Name
NM_016113.5 NP_057197.2 transient receptor potential cation channel subfamily V member 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables monoatomic cation channel activity IDA
IDA: 通过直接分析推断
10201375 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
34158856 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within response to temperature stimulus IDA
IDA: 通过直接分析推断
10201375 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
10201375 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRPV2 蛋白结构

Ank_2

Ank_2: Ankyrin repeats (3 copies) (167 - 257)

Ion_trans

Ion_trans: Ion transport protein (448 - 645)

  • 0
  • 200
  • 400
  • 600
  • 764 a.a.
蛋白主名 其他名称

transient receptor potential cation channel subfamily V member 2

OTRPC2

关联疾病

疾病名称 别名
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome

Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques

Palmoplantar And Periorificial Keratoderma

Olms
Scapuloperoneal Spinal Muscular Atrophy

SPSMA

Amyotrophy, Neurogenic Scapuloperoneal, New England Type

Neurogenic Scapuloperoneal Amyotrophy, New England Type

Scapuloperoneal Neuronopathy

Spinal Muscular Atrophy, Scapuloperoneal

Amyotrophy Neurogenic Scapuloperoneal New England Type

Muscular Atrophy, Spinal

Scapuloperoneal Form Of Spinal Muscular Atrophy
Brachyolmia

Brachyrachia
Dentin Sensitivity

Sensitive Dentin
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis

Hereditary Xerocytosis

Xerocytosis, Hereditary

Pshk1

Pseudohyperkalemia Edinburgh

Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema

DHS1

Dhs

Hereditary Desiccytosis

Dehydrated Hereditary Stomatocytosis 1

Desiccytosis, Hereditary

Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak

Pseudohyperkalemia Familial 1, Due To Red Cell Leak

Desiccytosis Hereditary

Xerocytosis Hereditary

Familial Pseudohyperkalemia 1 Due To Red Cell Leak

Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema

Xerocytosis
Lennox-Gastaut Syndrome

Lennox Syndrome

Encephalopathy Of Childhood

Epileptic Encephalopathy Lennox-Gastaut Type

Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

Lgs
Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy

Severe Myoclonic Epilepsy In Infancy

Smei

Epileptic Encephalopathy, Early Infantile, 6

DRVT

Developmental And Epileptic Encephalopathy 6a

Dee6a

Eiee6

Developmental And Epileptic Encephalopathy, 6

Dee6

Developmental And Epileptic Encephalopathy 6

Early Infantile Epileptic Encephalopathy 6

Myoclonic Epilepsy, Severe, Of Infancy

Sme

Severe Myoclonus Epilepsy Of Infancy

Borderline Smei

Smeb

Smeb-M

Smeb-O

Smeb-Sw

Smei-Borderland

Smei-Borderland More Than One Feature

Smei-Borderland-Myoclonic Seizures

Smei-Borderland-Spike Wave

Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures

ICEGTC

Infantile Severe Myoclonic Epilepsy

Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0545 Probenecid 99.95% 是
Pre-clinical Phase
生物活性分子 (8)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132222 SET2 Antagonist 99.72% 否
HY-157131 TRPV2-selective blocker 1 Inhibitor 99.84% 否
HY-B0545R Probenecid (Standard) 99.00% 否
HY-N8264 Moringin Agonist 99.95% 否
HY-B0545S Probenecid-d14 99.0% 否
HY-RS15122 TRPV2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N3230 Murpanicin Inhibitor / 否
HY-W404916 Probenecid sodium / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus TRPV2 MGD MGI:1341836
Rattus norvegicus TRPV2 RGD RGD:3965
Canis familiaris TRPV2 VGNC VGNC:47883
Macaca mulatta TRPV2 VGNC VGNC:79111
Felis catus TRPV2 VGNC VGNC:66596
Bos taurus TRPV2 VGNC VGNC:36398
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