ANAPC5 - anaphase promoting complex subunit 5 Gene

中文名称：后期促进复合亚基 5

种属: Homo sapiens

同用名: APC5

关于 ANAPC5

功能概要

该基因编码含有后期促进复合体/细胞周期体 (APC/C) 的四肽重复成分，这是一种大型 E3 泛素连接酶，通过靶向许多细胞周期调节因子 (例如 26S 蛋白酶体的 B 型细胞周期蛋白) 来控制细胞周期进程-通过泛素化介导的降解。编码的蛋白质对于 APC/C 的适当泛素化功能以及 APC/C 与转录共激活因子的相互作用是必需的。它还与 polyA 结合蛋白相互作用并抑制内部核糖体进入位点介导的翻译。已发现该基因编码不同异构体的多个转录变体。与异构体 a 相比，这些差异导致在下游 AUG 处开始翻译并导致更短的蛋白质 (异构体 b) 。[RefSeq 提供，2008 年 11 月]

This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin Ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]