2. Gene
  3. YTHDF2 - YTH N6-methyladenosine RNA binding protein 2 Gene

YTHDF2 - YTH N6-methyladenosine RNA binding protein 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：YTH N6-甲基腺苷 RNA 结合蛋白 2

种属: Homo sapiens

同用名: DF2; CAHL; HGRG8; NY-REN-2

基因 ID: 51441 | 基因类型: protein coding

关于 YTHDF2

Cytogenetic location: 1p35.3 Genomic coordinates (GRCh38): 1:28,736,624-28,769,775 (from NCBI)

This gene has 9 transcripts (splice variants), 214 orthologues and 3 paralogues. Ubiquitous expression in bone marrow (RPKM 23.8), testis (RPKM 20.2) and 25 other tissues.

功能概要

该基因编码包含 YTH 结构域的 YTH (YT521-B 同源) 超家族成员。 YTH 结构域是真核生物的典型结构域，在植物中尤为丰富。 YTH 结构域通常位于蛋白质序列的中间，可能与 RNA 结合。除了 YTH 结构域外，该蛋白质还有一个可能参与信号转导的富含脯氨酸的区域。已在该基因的一个内含子中鉴定出富含 Alu 的结构域，这被认为与人类长寿有关。此外，在急性髓性白血病患者中观察到该基因与 21 号染色体上的 Runx1 (AML1) 基因之间的相互易位。这个基因最初被映射到 14 号染色体，后来被证明是一个假基因。已在该基因中鉴定出编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 10 月]

This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in Plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]

YTHDF2 基因产物(3)

mRNA Protein Name
NM_001172828.2 NP_001166299.1 YTH domain-containing family protein 2 isoform 2
NM_001173128.2 NP_001166599.1 YTH domain-containing family protein 2 isoform 1
NM_016258.3 NP_057342.2 YTH domain-containing family protein 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables C5-methylcytidine-containing RNA reader activity IDA
IDA: 通过直接分析推断
31815440 GOA
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: 通过直接分析推断
22575960 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24965446 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA catabolic process IDA
IDA: 通过直接分析推断
27558897 GOA
involved in mRNA destabilization IDA
IDA: 通过直接分析推断
27558897 GOA
involved in mRNA destabilization IMP
IMP: 通过突变表型推断
28106072 GOA
involved in negative regulation of stem cell differentiation IMP
IMP: 通过突变表型推断
32169943 GOA
involved in negative regulation of type I interferon-mediated signaling pathway IMP
IMP: 通过突变表型推断
30559377 GOA
involved in organelle assembly IDA
IDA: 通过直接分析推断
31292544 GOA
involved in positive regulation of cap-independent translational initiation IDA
IDA: 通过直接分析推断
26458103 GOA
NOT involved in positive regulation of translational initiation IDA
IDA: 通过直接分析推断
32492408 GOA
involved in regulation of mRNA stability IDA
IDA: 通过直接分析推断
32492408 GOA
involved in regulation of mRNA stability IMP
IMP: 通过突变表型推断
24284625 GOA
involved in regulation of neurogenesis IMP
IMP: 通过突变表型推断
32169943 GOA
involved in regulation of rRNA processing IMP
IMP: 通过突变表型推断
31815440 GOA
involved in stress granule assembly IDA
IDA: 通过直接分析推断
32451507 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
24284625 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
32492408 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
31292544 GOA
located in cytosol IDA
IDA: 通过直接分析推断
26458103 GOA
located in nucleus IDA
IDA: 通过直接分析推断
26458103 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

YTHDF2 蛋白结构

YTH

YTH: YT521-B-like domain (411 - 545)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
蛋白主名 其他名称

YTH domain-containing family protein 2

9430020E02Rik

关联疾病

疾病名称 别名
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Ocular Melanoma

Intraocular Melanoma

Uveal Melanoma

Eye Melanoma

Melanoma Of Eye

Melanoma Of The Uvea

Malignant Melanoma Of Eye
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-154919 DC-Y13-27 99.52% 否
HY-RS15938 YTHDF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-168610 YTH-IN-1 / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus YTHDF2 VGNC VGNC:37042
Mus musculus YTHDF2 MGD MGI:2444233
Felis catus YTHDF2 VGNC VGNC:67152
Macaca mulatta YTHDF2 VGNC VGNC:79912
Rattus norvegicus YTHDF2 RGD RGD:1311321
Canis familiaris YTHDF2 VGNC VGNC:48506
Others YTHDF2 NCBI
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