2. Gene
  3. PDE7A - phosphodiesterase 7A Gene

PDE7A - phosphodiesterase 7A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 7A

种属: Homo sapiens

同用名: HCP1; PDE7

基因 ID: 5150 | 基因类型: protein coding

关于 PDE7A

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:65,714,334-65,842,064 (from NCBI)

This gene has 8 transcripts (splice variants), 240 orthologues and 20 paralogues. Broad expression in lymph node (RPKM 14.6), appendix (RPKM 7.7) and 23 other tissues.

功能概要

该基因编码的蛋白质属于环核苷酸磷酸二酯酶 (PDE) 家族和 PDE7 亚家族。该 PDE 水解第二信使 cAMP，它是许多细胞对细胞外信号反应的调节剂和介体。因此，通过调节 cAMP 的细胞浓度，这种蛋白质在许多重要的生理过程中起着关键作用。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

PDE7A 基因产物(5)

mRNA Protein Name
NM_002603.4 NP_002594.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform a precursor
NM_001242318.3 NP_001229247.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c
NM_002604.2
XM_011517540.4 XP_011515842.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1
XM_017013538.3 XP_016869027.1 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
IDA: 通过直接分析推断
8389765 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
9195912 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDE7A 蛋白结构

PDEase_I

PDEase_I: 3'5'-cyclic nucleotide phosphodiesterase (211 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 482 a.a.
蛋白主名 其他名称

high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A

TM22

high affinity cAMP-specific PDE 1

phosphodiesterase isozyme 7

关联疾病

疾病名称 别名
Low Compliance Bladder

Overactive Bladder

Hyperactivity Of Bladder

Hypertonic Bladder

Hypertonicity Of Bladder

Low Bladder Compliance

Oab - [Overactive Bladder]
Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell
Microphthalmia, Isolated 1

Isolated Microphthalmia 1

MCOP1

Mcop

Anophthalmia, Clinical, Isolated

Microphthalmos, Autosomal Recessive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-109586 BRL-50481 Inhibitor 99.85% 否
HY-146201 PDE4B/7A-IN-1 / 否
HY-146202 PDE4B/7A-IN-2 / 否
HY-RS10238 PDE7A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10239 Pde7a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10240 Pde7a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus PDE7A VGNC VGNC:68764
Rattus norvegicus PDE7A RGD RGD:68391
Mus musculus PDE7A MGD MGI:1202402
Bos taurus PDE7A VGNC VGNC:32685
Macaca mulatta PDE7A VGNC VGNC:75922
Canis familiaris PDE7A VGNC VGNC:44363
Others PDE7A NCBI
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