2. Gene
  3. UIMC1 - ubiquitin interaction motif containing 1 Gene

UIMC1 - ubiquitin interaction motif containing 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含泛素相互作用基序 1

种属: Homo sapiens

同用名: RAP80; X2HRIP110

基因 ID: 51720 | 基因类型: protein coding

关于 UIMC1

Cytogenetic location: 5q35.2 Genomic coordinates (GRCh38): 5:176,905,005-177,022,602 (from NCBI)

This gene has 14 transcripts (splice variants) and 189 orthologues. Broad expression in testis (RPKM 26.7), bone marrow (RPKM 12.5) and 24 other tissues.

功能概要

该基因编码一种核蛋白，该蛋白与复合物中的 Brca1 (乳腺癌 1) 相互作用，以识别和修复 DNA 损伤。该蛋白结合组蛋白 H2A 和 H2AX 的泛素化赖氨酸 63。这种蛋白质也可以作为转录抑制因子发挥作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 12 月]

This gene encodes a nuclear protein that interacts with Brca1 (breast Cancer 1) in a complex to recognize and repair DNA lesions. This protein binds ubiquitinated lysine 63 of histone H2A and H2AX. This protein may also function as a repressor of transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

UIMC1 基因产物(4)

mRNA Protein Name
NM_001199297.2 NP_001186226.1 BRCA1-A complex subunit RAP80 isoform 1
NM_001199298.2 NP_001186227.1 BRCA1-A complex subunit RAP80 isoform 1
NM_001317961.1 NP_001304890.1 BRCA1-A complex subunit RAP80 isoform 2
NM_016290.4 NP_057374.3 BRCA1-A complex subunit RAP80 isoform 1
蛋白主名 其他名称

BRCA1-A complex subunit RAP80

receptor-associated protein 80

UIMC1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra UIMC1 Q96RL1 ABRAXAS1 Homo sapiens Q6UWZ7
Anti Bait CoIP
17525340
Intra UIMC1 Q96RL1 ABRAXAS1 Homo sapiens Q6UWZ7
Anti Tag CoIP
19615732
Intra UIMC1 Q96RL1 BRCA1 Homo sapiens P38398
Anti Bait CoIP
17525340
Intra UIMC1 Q96RL1 BRCA1 Homo sapiens P38398
Pull Down
17525340
Intra UIMC1 Q96RL1 BLM Homo sapiens P54132
Anti Bait CoIP
23708797
Intra UIMC1 Q96RL1 DVL2 Homo sapiens O14641
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Fanconi Anemia, Complementation Group A

Fanconi Anemia

Fanconi Pancytopenia

Fanconi Anemia Complementation Group A

FANCA

Fa

Fanconi Panmyelopathy

Fanconi'S Anemia

Fanconi Anaemia

Fanconi'S Anaemia

Fanconi Hypoplastic Anemia

Estren-Dameshek Variant Of Fanconi Anemia

Estren-Dameshek Variant Of Fanconi Pancytopenia

Fanconi Anemia Estren-Dameshek Variant

Fanconis Anemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15447 UIMC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UIMC1 RGD RGD:1307009
Mus musculus UIMC1 MGD MGI:103185
Bos taurus UIMC1 VGNC VGNC:36657
Canis familiaris UIMC1 VGNC VGNC:48127
Macaca mulatta UIMC1 VGNC VGNC:79842
Felis catus UIMC1 VGNC VGNC:66813
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