2. Gene
  3. LUC7L3 - LUC7 like 3 pre-mRNA splicing factor Gene

LUC7L3 - LUC7 like 3 pre-mRNA splicing factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LUC7 like 3 pre-mRNA 剪接因子

种属: Homo sapiens

同用名: CRA; CROP; LUC7A; hLuc7A; CREAP-1; OA48-18

基因 ID: 51747 | 基因类型: protein coding

关于 LUC7L3

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,719,603-50,756,219 (from NCBI)

This gene has 23 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 53.0), ovary (RPKM 46.4) and 25 other tissues.

功能概要

该基因编码的蛋白质的 N 端一半包含半胱氨酸/组氨酸基序和亮氨酸拉链样重复序列，C 端一半富含精氨酸和谷氨酸残基 (RE 域) 以及精氨酸和丝氨酸残基 (RS 域) .这种蛋白质在细胞核中以斑点模式定位，并可能通过 RE 和 RS 结构域参与剪接体的形成。已经为该基因发现了编码相同蛋白质的两个选择性剪接的转录物变体。[RefSeq 提供，2009 年 8 月]

This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]

LUC7L3 基因产物(3)

mRNA Protein Name
NM_001330330.2 NP_001317259.1 luc7-like protein 3 isoform 2
NM_006107.4 NP_006098.2 luc7-like protein 3 isoform 1
NM_016424.5 NP_057508.2 luc7-like protein 3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables mRNA binding IMP
IMP: 通过突变表型推断
10631324 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15798186 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in RNA splicing IMP
IMP: 通过突变表型推断
10631324 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
12565863 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LUC7L3 蛋白结构

LUC7

LUC7: LUC7 N_terminus (5 - 252)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

luc7-like protein 3

CRE-associated protein 1

关联疾病

疾病名称 别名
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07890 LUC7L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris LUC7L3 VGNC VGNC:42864
Mus musculus LUC7L3 MGD MGI:1914934
Rattus norvegicus LUC7L3 RGD RGD:1307981
Felis catus LUC7L3 VGNC VGNC:63328
Macaca mulatta LUC7L3 VGNC VGNC:74346
Bos taurus LUC7L3 VGNC VGNC:31080
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