CALML5 - calmodulin like 5 Gene

中文名称：钙调蛋白样 5

种属: Homo sapiens

同用名: CLSP

关于 CALML5

功能概要

该基因编码一种在表皮中表达的新型钙结合蛋白，与钙结合蛋白的钙调蛋白家族有关。对重组蛋白的功能研究表明它确实结合钙并在结合时发生构象变化。仅在重建的表皮中检测到大量表达，并且仅限于分化的角质形成细胞。此外，它还可以与转谷氨酰胺酶 3 结合，转谷氨酰胺酶 3 被证明是角质形成细胞终末分化的关键酶。[RefSeq 提供，2008 年 7 月]

This gene encodes a novel calcium binding protein expressed in the epidermis and related to the Calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key Enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]