2. Gene
  3. PGK2 - phosphoglycerate kinase 2 Gene

PGK2 - phosphoglycerate kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：磷酸甘油酸激酶 2

种属: Homo sapiens

同用名: PGKB; PGKPS; HEL-S-272; dJ417L20.2

基因 ID: 5232 | 基因类型: protein coding

关于 PGK2

Cytogenetic location: 6p12.3 Genomic coordinates (GRCh38): 6:49,785,660-49,787,285 (from NCBI)

This gene has 1 transcript (splice variant), 194 orthologues and 1 paralogue.

功能概要

该基因是无内含子的，通过磷酸甘油酸激酶 1 基因的逆转录转座产生，并在睾丸中特异性表达。最初被认为是假基因，所编码的蛋白质实际上是一种功能性磷酸甘油酸激酶，在精子发生后期的 Embden-Meyerhof-Parnas 糖酵解途径中，催化 1,3-二磷酸甘油酸向 3-磷酸甘油酸的可逆转化。[RefSeq 提供，2010 年 5 月]

This gene is intronless, arose via retrotransposition of the phosphoglycerate kinase 1 gene, and is expressed specifically in the testis. Initially assumed to be a pseudogene, the encoded protein is actually a functional phosphoglycerate kinase that catalyzes the reversible conversion of 1,3-bisphosphoglycerate to 3-phosphoglycerate, during the Embden-Meyerhof-Parnas pathway of glycolysis, in the later stages of spermatogenesis.[provided by RefSeq, May 2010]

PGK2 基因产物(1)

mRNA Protein Name
NM_138733.5 NP_620061.2 phosphoglycerate kinase 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphoglycerate kinase activity EXP
EXP: 通过实验结果推断
1278465 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PGK2 蛋白结构

PGK

PGK: Phosphoglycerate kinase (8 - 406)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
蛋白主名 其他名称

phosphoglycerate kinase 2

epididymis secretory protein Li 272

PGK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PGK2 P07205 PGK1 Homo sapiens P00558
Anti Tag CoIP
33961781
种属内
PGK2 P07205 PGK1 Homo sapiens P00558
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PGK2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75972 PGK2 Protein, Human (sf9, His) P07205 (S2-M417) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 58

IMD58

Severe Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Rltpr Deficiency
Phosphoglycerate Kinase 1 Deficiency

Pgk1 Deficiency

Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency

Phosphoglycerate Kinase Deficiency

Pgk Deficiency

Glycogenosis Due To Phosphoglycerate Kinase 1 Deficiency

Gsd Due To Phosphoglycerate Kinase 1 Deficiency

Deficiency Of Phosphoglycerate Kinase

PGK1D

Deficiency, Phosphoglycerate Kinase 1
Testicular Torsion

Spermatic Cord Torsion

Torsion Of Testis

Torsion Of Testicular Cord

Torsion Of Testicle

Torsion Of Spermatic Cord

Torsion Of Spermatic Cord Nos
Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10385 PGK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-120656 Prostaglandin K2 / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta PGK2 VGNC VGNC:75966
Felis catus PGK2 VGNC VGNC:68815
Mus musculus PGK2 MGD MGI:97563
Rattus norvegicus PGK2 RGD RGD:1306627
Others PGK2 NCBI
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