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  3. SERPINI2 - serpin family I member 2 Gene

SERPINI2 - serpin family I member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：serpin 家族成员 2

种属: Homo sapiens

同用名: MEPI; PI14; PANCPIN; TSA2004

基因 ID: 5276 | 基因类型: protein coding

关于 SERPINI2

Cytogenetic location: 3q26.1 Genomic coordinates (GRCh38): 3:167,441,933-167,476,963 (from NCBI)

This gene has 8 transcripts (splice variants), 104 orthologues and 36 paralogues. Restricted expression toward pancreas (RPKM 124.3).

功能概要

该基因编码作为丝氨酸蛋白酶抑制剂的蛋白质家族成员。这些蛋白质在调节各种生理过程中发挥作用，包括凝血、纤维蛋白溶解、发育、恶性肿瘤和炎症。在胰腺癌发生过程中，编码蛋白的表达可能会下调。可变剪接导致该基因的多个转录变体。[RefSeq 提供，2013 年 1 月]

The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]

SERPINI2 基因产物(3)

mRNA Protein Name
NM_001012303.3 NP_001012303.2 serpin I2 precursor
NM_001394327.1 NP_001381256.1 serpin I2 precursor
NM_006217.6 NP_006208.1 serpin I2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINI2 蛋白结构

Serpin

Serpin: Serpin (serine protease inhibitor) (25 - 392)

  • 0
  • 100
  • 200
  • 300
  • 405 a.a.
蛋白主名 其他名称

serpin I2

myoepithelium-derived serine protease inhibitor

SERPINI2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
种属内
SERPINI2 O75830 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
SERPINI2 O75830 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
25416956
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
16713569
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
种属内
SERPINI2 O75830 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
种属内
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H
21516116
种属内
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
SERPINI2 O75830 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
种属内
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Validated Y2H
32296183
种属内
SERPINI2 O75830 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
种属内
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
种属内
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属内
SERPINI2 O75830 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINI2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71039 Serpin I2 Protein, Human (HEK293, His) O75830 (S19-L405 ) ≥95%

关联疾病

疾病名称 别名
Retinitis Pigmentosa 61

RP61

Retinitis Pigmentosa, Type 61
Cardiomyopathy, Dilated, 1o

Dilated Cardiomyopathy 1o

CMD1O

Dilated Cardiomyopathy With Ventricular Tachycardia

Cardiomyopathy, Dilated, With Ventricular Tachycardia

Cardiomyopathy, Dilated 1o

Cardiomyopathy, Dilated, Type 1o
Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies

FENIB

Encephalopathy, Familial, With Collins Bodies

Familial Dementia With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Collins Bodies
Corneal Dystrophy, Meesmann, 1

Meesmann Corneal Dystrophy

Mecd

Corneal Dystrophy, Meesmann Epithelial

Juvenile Hereditary Epithelial Dystrophy

Corneal Dystrophy, Juvenile Epithelial Of Meesmann

MECD1

Meesmann Corneal Dystrophy 1

Meesmann Corneal Epithelial Dystrophy

Meesmann Epithelial Corneal Dystrophy

Corneal Dystrophy, Juvenile Epithelial, Of Meesmann

Stocker-Holt Dystrophy

Meesman Dystrophy

Meesman'S Corneal Dystrophy

Juvenile Hereditary Epithelial Dystrophy Of Meesmann

Corneal Dystrophy, Meesmann 1

Juvenile Epithelial Corneal Dystrophy Of Meesmann

Mcd

Dystrophy, Corneal, Meesmann
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12730 SERPINI2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SERPINI2 MGD MGI:1915181
Macaca mulatta SERPINI2 VGNC VGNC:77367
Canis familiaris SERPINI2 VGNC VGNC:46043
Felis catus SERPINI2 VGNC VGNC:68835
Bos taurus SERPINI2 VGNC VGNC:34482
Rattus norvegicus SERPINI2 RGD RGD:619897
Others SERPINI2 NCBI
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