2. Gene
  3. LRP1B - LDL receptor related protein 1B Gene

LRP1B - LDL receptor related protein 1B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LDL 受体相关蛋白 1B

种属: Homo sapiens

同用名: LRP-1B; LRPDIT; LRP-DIT

基因 ID: 53353 | 基因类型: protein coding

关于 LRP1B

Cytogenetic location: 2q22.1-q22.2 Genomic coordinates (GRCh38): 2:140,231,423-142,131,016 (from NCBI)

This gene has 5 transcripts (splice variants), 233 orthologues, 14 paralogues and is associated with 159 phenotypes. Biased expression in brain (RPKM 3.0), thyroid (RPKM 1.8) and 4 other tissues.

功能概要

该基因编码低密度脂蛋白 (LDL) 受体家族的成员。由于它们与多种配体的相互作用，这些受体在正常细胞功能和发育中发挥着广泛的作用。在几种类型的癌症中已经报道了这种基因的破坏。[RefSeq 提供，2016 年 6 月]

This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of Cancer. [provided by RefSeq, Jun 2016]

LRP1B 基因产物(1)

mRNA Protein Name
NM_018557.3 NP_061027.2 low-density lipoprotein receptor-related protein 1B precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LRP1B 蛋白结构

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (32 - 69)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (76 - 113)

EGF_CA

EGF_CA: Calcium-binding EGF domain (155 - 193)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (295 - 335)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (568 - 608)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (611 - 654)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (659 - 703)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (798 - 833)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (845 - 881)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (885 - 922)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (926 - 962)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (965 - 1002)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1005 - 1042)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1052 - 1088)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (1095 - 1131)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (1176 - 1212)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1347 - 1387)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1392 - 1434)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1619 - 1658)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (1838 - 1874)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (1965 - 2005)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2008 - 2049)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (2330 - 2372)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2510 - 2543)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2551 - 2586)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2589 - 2625)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2644 - 2674)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2681 - 2716)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2719 - 2753)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2760 - 2797)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2804 - 2840)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2844 - 2882)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (2890 - 2925)

cEGF

cEGF: Complement Clr-like EGF-like (2948 - 2971)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (3056 - 3096)

FXa_inhibition

FXa_inhibition: Coagulation Factor Xa inhibitory site (3277 - 3313)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3315 - 3352)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3356 - 3391)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3395 - 3431)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3435 - 3471)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3474 - 3510)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3514 - 3549)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3552 - 3587)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3592 - 3628)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3631 - 3667)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3674 - 3710)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (3761 - 3796)

EGF_CA

EGF_CA: Calcium-binding EGF domain (3844 - 3880)

Ldl_recept_b

Ldl_recept_b: Low-density lipoprotein receptor repeat class B (4040 - 4080)

EGF

EGF: EGF-like domain (4254 - 4283)

  • 0
  • 800
  • 1600
  • 2400
  • 3200
  • 4000
  • 4599 a.a.
蛋白主名 其他名称

low-density lipoprotein receptor-related protein 1B

LRP-deleted in tumors

关联疾病

疾病名称 别名
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Male Urethral Cancer

Male Urethral Malignant Neoplasm
Meier-Gorlin Syndrome 2

MGORS2

Meier-Gorlin Syndrome, Type 2
Epilepsy, Idiopathic Generalized 9

Epilepsy, Idiopathic Generalized, Susceptibility To, 9

EIG9

Epilepsy, Juvenile Myoclonic 6

Idiopathic Generalized Epilepsy 9

Epilepsy, Juvenile Myoclonic, Susceptibility To, 6

Susceptibility To Idiopathic Generalized Epilepsy 9

Juvenile Myoclonic Epilepsy 6

EJM6

Susceptibility To Juvenile Myoclonic Epilepsy 6

Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 9
Hypermethioninemia Due To Adenosine Kinase Deficiency

Adk Hypermethioninemia

Hypermethioninemia Encephalopathy Due To Adenosine Kinase Deficiency

Hypermethioninemia Encephalopathy Due To Adk Deficiency

Mrt8

Mental Retardation, Autosomal Recessive 8, Formerly

Mrt8, Formerly

HMAKD

Mental Retardation, Autosomal Recessive 8
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LRP1B RGD RGD:1306160
Macaca mulatta LRP1B VGNC VGNC:74443
Mus musculus LRP1B MGD MGI:2151136
Canis familiaris LRP1B VGNC VGNC:42774
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