1. Gene
  2. POLR2I - RNA polymerase II subunit I Gene

POLR2I - RNA polymerase II subunit I Gene

中文名称:RNA 聚合酶 II 亚基 I

种属: Homo sapiens

同用名: RPB9; hRPB14.5

基因 ID: 5438 | 基因类型: protein coding

关于 POLR2I

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,113,709-36,114,875 (from NCBI)

This gene has 7 transcripts (splice variants), 192 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 23.3), brain (RPKM 15.2) and 25 other tissues.

功能概要

该基因编码 RNA 聚合酶 II 的一个亚基,该聚合酶负责在真核生物中合成信使 RNA。该亚基与其他两个聚合酶亚基结合,形成聚合酶的 DNA 结合域,即 DNA 模板在其中转录成 RNA 的凹槽。该基因的产物具有两个具有保守半胱氨酸的锌指基序,并且该亚基确实具有锌结合活性。[RefSeq 提供,2008 年 7 月]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two Other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity. [provided by RefSeq, Jul 2008]

POLR2I 基因产物(1)

mRNA Protein Name
NM_006233.5 NP_006224.1 DNA-directed RNA polymerase II subunit RPB9
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9852112 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II, core complex IDA
IDA: 通过直接分析推断
9852112 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9852112 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

POLR2I 蛋白结构

RNA_POL_M_15KD

RNA_POL_M_15KD: RNA polymerases M/15 Kd subunit (14 - 51)

TFIIS_C

TFIIS_C: Transcription factor S-II (TFIIS) (84 - 124)

  • 0
  • 100
  • 125 a.a.
蛋白主名 其他名称

DNA-directed RNA polymerase II subunit RPB9

DNA-directed RNA polymerase II 14.5 kDa polypeptide

关联疾病

疾病名称 别名
Polyomavirus-Associated Nephropathy

Polyomavirus Associated Nephropathy

Pvan

Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris POLR2I VGNC VGNC:44798
Felis catus POLR2I VGNC VGNC:68954
Macaca mulatta POLR2I VGNC VGNC:76217
Bos taurus POLR2I VGNC VGNC:33143
Mus musculus POLR2I MGD MGI:1917170
Rattus norvegicus POLR2I RGD RGD:1309395