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  2. IL17RD - interleukin 17 receptor D Gene

IL17RD - interleukin 17 receptor D Gene

中文名称:白介素 17 受体 D

种属: Homo sapiens

同用名: SEF; HH18; IL-17RD; IL17RLM

基因 ID: 54756 | 基因类型: protein coding

关于 IL17RD

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:57,089,982-57,170,317 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues, 4 paralogues and is associated with 2 phenotypes. Broad expression in endometrium (RPKM 8.3), testis (RPKM 6.2) and 14 other tissues.

功能概要

该基因编码一种属于白细胞介素 17 受体 (IL-17R) 蛋白家族的膜蛋白。编码的蛋白质是白细胞介素 17 受体信号复合物的组成部分,该蛋白质与 IL-17R 之间的相互作用不需要白细胞介素。该基因产物还影响成纤维细胞生长因子信号,通过 MAPK/ERK 信号抑制或刺激生长。交替剪接生成编码不同亚型的多个转录变体。[RefSeq 提供,2016 年 1 月]

This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects Fibroblast Growth Factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

IL17RD 基因产物(2)

mRNA Protein Name
NM_001318864.2 NP_001305793.1 interleukin-17 receptor D isoform b
NM_017563.5 NP_060033.3 interleukin-17 receptor D isoform a precursor

IL17RD 蛋白结构

SEFIR

SEFIR: SEFIR domain (356 - 511)

  • 0
  • 200
  • 400
  • 600
  • 739 a.a.
蛋白主名 其他名称

interleukin-17 receptor D

IL-17 receptor D

重组 IL17RD 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72578 IL-17RD Protein, Human (283a.a, HEK293, His) Q8NFM7-1(C17-R299) ≥95%

关联疾病

疾病名称 别名
Hypogonadotropic Hypogonadism 18 With Or Without Anosmia

HH18

Hypogonadism, Hypogonadotropic, Type 18 With/Without Anosmia

Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Arteriovenous Malformations Of The Brain

Cerebral Arteriovenous Malformation

Intracranial Arteriovenous Malformation

Intracranial Hemorrhage In Brain Cerebrovascular Malformations, Susceptibility To

Intracranial Arteriovenous Malformations

Bavm

Cerebral Arteriovenous Malformations

Intracranial Hemorrhage In Brain Cerebrovascular Malformations

Arteriovenous Malformation Of The Brain, Somatic

Intracranial Avm

Arteriovenous Malformations Cerebral

Hypogonadotropic Hypogonadism

Klinefelter Syndrome

Klinefelter'S Syndrome

Xxy Syndrome

Xxy Trisomy

Hypogonadotropism

47, Xxy

Congenital Idiopathic Hypogonadotropic Hypogonadism

Isolated Congenital Gonadotropin Deficiency

47,Xxy Syndrome

47, Xxy Syndrome

Klinefelters Syndrome

Hypogonadism

Klinefelter Syndrome In Males

Klinefelter Syndrome, Unspecified

Klinefelter Syndrome Karyotype 47, Xxy

Hypogonadism
Seborrheic Infantile Dermatitis

Cradle Cap

Infantile Seborrhoeic Dermatitis

Seborrhoea Capitis

Seborrhoeic Dermatitis Of Scalp

Seborrhoeic Eczema Of Scalp

Complement 5 Dysfunction

Generalized Seborrheic Dermatitis Of Infants

Infantile Seborrheic Dermatitis

Pityriasis Capitis

Seborrhea Capitis

Seborrhea Sicca

Dandruff

Complement Component 5 Deficiency

Seborrheic Dermatitis

Seborrheic Dermatitis Of Scalp

Scurfiness Of Scalp

Seborrheic Dermatitis Of Infancy

Infantile Seborrhoeic Eczema

Neonatal Seborrhoeic Dermatitis

Infantile Seborrhoeic Dermatitis Of The Scalp

Sensorineural Hearing Loss

Sensory Hearing Loss

Sensorineural Deafness

Sensorineural Hearing Loss Disorder

Hearing Loss, Sensorineural

Central Hearing Loss

High Frequency Deafness

High Frequency Hearing Loss

High-Frequency Hearing Loss

Perceptive Deafness

Perceptive Hearing Loss

Perceptive Hearing Loss Or Deafness

Hearing Loss Sensorineural

Deafness Sensorineural

Hearing Loss High-Frequency

Hearing Loss, Central

Hearing Loss, High-Frequency

Double Outlet Right Ventricle

Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect

Taussig-Bing Syndrome

Dextrotransposition Of Aorta

Taussig-Bing Syndrome Or Defect

Dorv

Dorv With Subpulmonary Vsd

Dorv-Tga

Double Outlet Right Ventricle With Transposition Of The Great Arteries

Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type

Taussig-Bing Heart

Taussig-Bing Malformation

Taussig-Bing Complex

Taussig-Bing Defect

Taussig-Bing

Double Outlet Right Ventricle With Remote Ventricular Septal Defect

Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect

Double Outlet Right Ventricle With Non-Committed Interventricular Communication

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis

Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis

Renal Hypodysplasia/Aplasia 1

Renal Agenesis

Renal Adysplasia

Renal Aplasia

RHDA1

Hereditary Renal Aplasia

Hra

Hereditary Urogenital Adysplasia

Hypodysplasia/Aplasia, Renal, Type 1

Congenital Absence Of Kidneys Syndrome

Congenital Absence Of Kidney

Aplastic Kidney

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL17RD RGD RGD:1565237
Macaca mulatta IL17RD VGNC VGNC:73614
Canis familiaris IL17RD VGNC VGNC:41949
Mus musculus IL17RD MGD MGI:2159727
Bos taurus IL17RD VGNC VGNC:30124
Felis catus IL17RD VGNC VGNC:62904
Others IL17RD NCBI