PGPEP1 - pyroglutamyl-peptidase I Gene

中文名称：焦谷氨酰肽酶 I

种属: Homo sapiens

同用名: PGI; PGP; Pcp; PGPI; PAP-I; PGP-I

关于 PGPEP1

功能概要

该基因编码半胱氨酸蛋白酶和肽酶 C15 蛋白家族的成员。编码的蛋白质从蛋白质底物 (包括促甲状腺激素释放激素和其他神经肽) 上切割氨基末端焦谷氨酸残基。该基因的表达可能在结直肠癌中下调，而编码蛋白的活性可能与结直肠癌患者的癌症进展呈负相关。编码的蛋白酶的活性也可能在其他疾病状态下发生改变，包括与蛋白酶活性降低相关的肝硬化和与蛋白酶活性升高相关的坏死精子症。[RefSeq 提供，2016 年 7 月]

The gene encodes a cysteine protease and member of the peptidase C15 family of proteins. The encoded protein cleaves amino terminal pyroglutamate residues from protein substrates including thyrotropin-releasing hormone and Other neuropeptides. Expression of this gene may be downregulated in colorectal Cancer, while activity of the encoded protein may be negatively correlated with Cancer progression in colorectal Cancer patients. Activity of the encoded protease may also be altered in Other disease states including in liver cirrhosis, which is associated with reduced protease activity, and in necrozoospermia, which is associated with elevated protease activity. [provided by RefSeq, Jul 2016]