1. Gene
  2. SIRPG - signal regulatory protein gamma Gene

SIRPG - signal regulatory protein gamma Gene

中文名称:信号调节蛋白γ

种属: Homo sapiens

同用名: CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma

基因 ID: 55423 | 基因类型: protein coding

关于 SIRPG

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:1,629,152-1,686,455 (from NCBI)

This gene has 7 transcripts (splice variants), 281 orthologues and 4 paralogues. Biased expression in lymph node (RPKM 13.6), appendix (RPKM 6.0) and 8 other tissues.

功能概要

该基因编码的蛋白质是信号调节蛋白 (SIRP) 家族的一员,也属于免疫球蛋白超家族。 SIRP 家族成员是受体型跨膜糖蛋白,已知参与受体酪氨酸激酶偶联信号传导过程的负调节。已经描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

SIRPG 基因产物(3)

mRNA Protein Name
NM_001039508.2 NP_001034597.1 signal-regulatory protein gamma isoform 3 precursor
NM_018556.4 NP_061026.2 signal-regulatory protein gamma isoform 1 precursor
NM_080816.3 NP_543006.2 signal-regulatory protein gamma isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
15383453 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of T cell activation IDA
IDA: 通过直接分析推断
15383453 GOA
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15383453 GOA
involved in positive regulation of cell-cell adhesion IDA
IDA: 通过直接分析推断
15383453 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
15383453 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SIRPG 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (33 - 128)

C1-set

C1-set: Immunoglobulin C1-set domain (160 - 234)

C1-set

C1-set: Immunoglobulin C1-set domain (261 - 335)

  • 0
  • 100
  • 200
  • 300
  • 387 a.a.
蛋白主名 其他名称

signal-regulatory protein gamma

CD172 antigen-like family member B

SIRPG 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SIRPG Q9P1W8 CD47 Homo sapiens Q08722
FACS
15383453
种属内
SIRPG Q9P1W8 GATM Homo sapiens P50440
Y2H Array
32814053
种属内
SIRPG Q9P1W8 GATM Homo sapiens P50440
Validated Y2H
32814053
种属内
SIRPG Q9P1W8 GATM Homo sapiens P50440
Y2H Pooling
32814053
种属内
SIRPG Q9P1W8 FOS Homo sapiens P01100
Validated Y2H
32814053
种属内
SIRPG Q9P1W8 FOS Homo sapiens P01100
Y2H Array
32814053
种属内
SIRPG Q9P1W8 FOS Homo sapiens P01100
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SIRPG 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71316 SIRP gamma Protein, Human (HEK293, Fc) Q9P1W8-1(E29-P360) ≥95%
HY-P78210 SIRP gamma Protein, Human (Biotinylated, HEK293, His-Avi) Q9P1W8-1 (E29-P360) ≥95%
HY-P78521 SIRP gamma Protein, Human (HEK293, His-Avi) Q9P1W8-1 (E29-P360) ≥95%

关联疾病

疾病名称 别名
Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome

Rh Disease

HDFNRH

Rh Fetomaternal Incompatibility

Rh-Null Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca fascicularis SIRPG NCBI
Others SIRPG NCBI