2. Gene
  3. IL17RB - interleukin 17 receptor B Gene

IL17RB - interleukin 17 receptor B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白介素 17 受体 B

种属: Homo sapiens

同用名: CRL4; EVI27; IL17BR; IL17RH1

基因 ID: 55540 | 基因类型: protein coding

关于 IL17RB

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:53,846,568-53,865,794 (from NCBI)

This gene has 3 transcripts (splice variants), 142 orthologues and 4 paralogues. Broad expression in kidney (RPKM 18.0), liver (RPKM 7.7) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种细胞因子受体。该受体特异性结合 IL17B 和 IL17E，但不结合 IL17 和 IL17C。该受体已被证明可介导 NF-kappaB 的激活和由 IL17E 诱导的 IL8 的产生。发现该基因的大鼠对应物的表达在肠道炎症期间显着上调，这表明该受体的免疫调节活性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]

IL17RB 基因产物(1)

mRNA Protein Name
NM_018725.4 NP_061195.2 interleukin-17 receptor B precursor

IL17RB 蛋白结构

SEFIR

SEFIR: SEFIR domain (333 - 479)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 502 a.a.
蛋白主名 其他名称

interleukin-17 receptor B

IL-17 receptor B

IL17RB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IL17RB Q9NRM6 DAZAP2 Homo sapiens Q15038
Y2H
22070932
种属内
IL17RB Q9NRM6 DAZAP2 Homo sapiens Q15038
Pull Down
22070932
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 IL17RB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72581 IL-17RB Protein, Human (HEK293, His) Q9NRM6-1 (R18-G289) ≥95%
HY-P76419 IL-17RB Protein, Human (HEK293, Fc) Q9NRM6-1 (R18-G289) ≥95%

关联疾病

疾病名称 别名
Herpes Zoster

Shingles

Zoster

Herpes Zona

Herpes Zoster Disease

Zona Zoster

Herpes Zoster Of Skin And Mucous Membranes

Zoster Nos

Zoster With Nervous System Involvement
Parasitic Helminthiasis Infectious Disease

Helminthiasis

Intestinal Helminthiasis

Helminth Infection

Helminthosis

Worm Infection

Worm Infections

Helminth Infections

Intestinal Infection Due To Class Cestoda And/Or Class Trematoda And/Or Phylum Nemata

Parasitic Enteritis

Metazoal Dysentery

Intestinal Worms Nos
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06703 IL17RB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris IL17RB VGNC VGNC:41947
Mus musculus IL17RB MGD MGI:1355292
Rattus norvegicus IL17RB RGD RGD:1311392
Felis catus IL17RB VGNC VGNC:62902
Macaca mulatta IL17RB VGNC VGNC:73618
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