2. Gene
  3. PKIB - cAMP-dependent protein kinase inhibitor beta Gene

PKIB - cAMP-dependent protein kinase inhibitor beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：cAMP 依赖性蛋白激酶抑制因子 β

种属: Homo sapiens

同用名: PRKACN2

基因 ID: 5570 | 基因类型: protein coding

关于 PKIB

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,471,921-122,726,373 (from NCBI)

This gene has 13 transcripts (splice variants), 112 orthologues and 2 paralogues. Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues.

功能概要

该基因编码 cAMP 依赖性蛋白激酶抑制剂家族的成员。编码的蛋白质可能通过与 PKA 的催化亚基相互作用在蛋白激酶 A (PKA) 通路中发挥作用，并且该基因的过表达可能在前列腺癌中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2012 年 7 月]

This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate Cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

PKIB 基因产物(6)

mRNA Protein Name
NM_001270393.2 NP_001257322.1 cAMP-dependent protein kinase inhibitor beta isoform 1
NM_001270394.2 NP_001257323.1 cAMP-dependent protein kinase inhibitor beta isoform 2
NM_001270395.2 NP_001257324.1 cAMP-dependent protein kinase inhibitor beta isoform 2
NM_032471.6 NP_115860.1 cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181794.3 NP_861459.1 cAMP-dependent protein kinase inhibitor beta isoform 1
NM_181795.3 NP_861460.1 cAMP-dependent protein kinase inhibitor beta isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of positive regulation of telomere maintenance IMP
IMP: 通过突变表型推断
21531765 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKIB 蛋白结构

PKI

PKI: cAMP-dependent protein kinase inhibitor (9 - 77)

  • 0
  • 78 a.a.
蛋白主名 其他名称

cAMP-dependent protein kinase inhibitor beta

PKI-beta

重组 PKIB 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71209 PKI-beta Protein, Human (His) Q9C010-1 (M1-K78) ≥95%

关联疾病

疾病名称 别名
Benign Essential Hypertension
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10599 PKIB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PKIB VGNC VGNC:44608
Bos taurus PKIB VGNC VGNC:32941
Mus musculus PKIB MGD MGI:101937
Rattus norvegicus PKIB RGD RGD:3335
Felis catus PKIB VGNC VGNC:68875
Macaca mulatta PKIB VGNC VGNC:83443
Others PKIB NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z