SLC22A11 - solute carrier family 22 member 11 Gene

中文名称：溶质载体家族 22 成员 11

种属: Homo sapiens

同用名: OAT4; hOAT4

基因 ID: 55867 | 基因类型: protein coding

关于 SLC22A11

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,555,941-64,572,875 (from NCBI)

This gene has 8 transcripts (splice variants), 891 orthologues and 22 paralogues. Biased expression in placenta (RPKM 19.0) and kidney (RPKM 17.4).

功能概要

该基因编码的蛋白质参与了有机阴离子的非钠依赖性转运和排泄，其中一些具有潜在毒性。编码的蛋白质是一种完整的膜蛋白，主要存在于肾脏和胎盘中，在那里它可能起到防止潜在有害有机阴离子到达胎儿的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 4 月]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

SLC22A11 基因产物(2)

mRNA	Protein	Name
NM_001307985.2	NP_001294914.1	solute carrier family 22 member 11 isoform 2
NM_018484.4	NP_060954.1	solute carrier family 22 member 11 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables organic anion transmembrane transporter activity	IDA IDA: 通过直接分析推断	11907186	GOA
enables prostaglandin transmembrane transporter activity	IDA IDA: 通过直接分析推断	11907186	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16236806	GOA
enables sodium-independent organic anion transmembrane transporter activity	IDA IDA: 通过直接分析推断	10660625	GOA
enables solute:inorganic anion antiporter activity	IDA IDA: 通过直接分析推断	15037815	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in organic anion transport	IDA IDA: 通过直接分析推断	10660625	GOA
involved in prostaglandin transport	IDA IDA: 通过直接分析推断	11907186	GOA
involved in urate metabolic process	IMP IMP: 通过突变表型推断	19503597	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical plasma membrane	IDA IDA: 通过直接分析推断	15037815	GOA
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	15102942	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	10660625	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC22A11 蛋白结构

Sugar_tr

0
100
200
300
400
500
550 a.a.

蛋白主名

其他名称

solute carrier family 22 member 11

organic anion transporter 4

关联疾病

疾病名称

别名

Nephrolithiasis, Uric Acid

Nephrolithiasis, Uric Acid, Susceptibility To	Uric Acid Urolithiasis
Uric Acid Nephrolithiasis	UAN
Acute Urate Nephropathy	Urolithiasis, Uric Acid
Urolithiasis, Uric Acid, Susceptibility To	Uric Acid Renal Calculus

Gout

Gouty Arthritis	Articular Gout
Gouty Arthropathy	Arthritis, Gouty
Arthritis Gouty	Idiopathic Gout
Idiopathic Gout, Unspecified Site	Gouty Bursitis
Uratic Arthritis	Gout Nos
Gouty	Gouty Diathesis

Tubulointerstitial Kidney Disease, Autosomal Dominant, 1

Familial Juvenile Hyperuricemic Nephropathy	Mckd2
Familial Juvenile Hyperuricemic Nephropathy Type 1	Fjhn
Medullary Cystic Kidney Disease 2	Uromodulin-Associated Kidney Disease
Medullary Cystic Kidney Disease Type 2	ADTKD1
Hnfj1	Glomerulocystic Kidney Disease With Hyperuricemia And Isosthenuria
Adtkd-Umod	Familial Juvenile Hyperuricemic Nephropathy 1
Umod-Related Adtkd	Umod-Related Autosomal Dominant Tubulointerstitial Kidney Disease
Hyperuricemic Nephropathy, Familial Juvenile, 1	Gouty Nephropathy, Familial Juvenile
Medullary Cystic Kidney Disease 2, Autosomal Dominant	Admckd2
Autosomal Dominant Tubulointerstitial Kidney Disease Due To Umod Mutations	Adtkd Due To Umod Mutations
Autosomal Dominant Tubulointerstitial Kidney Disease, Umod-Related	Autosomal Dominant Medullary Cystic Kidney Disease Type 2
Umod-Associated Kidney Disease	Uromodulin Kidney Disease
Familial Gout-Kidney Disease	Familial Gouty Nephropathy
Umak	Umod-Related Kidney Disease
Uromodulin Storage Disease	Fjhn1
Gouty Nephropathy Familial Juvenile	Nephropathy Familial With Gout
Hyperuricemic Nephropathy, Familial Juvenile 1	Hyperuricemic Nephropathy, Familial Juvenile
Kidney Disease, Glomerulocystic, With Hyperuricemia And Isosthenuria	Nephropathy, Hyperuricemic, Juvenile, Familial, Type 1
Kidney Disease, Cystic, Medullary, Type 2	Medullary Cystic Kidney Disease Type Ii
Familial Juvenile Gout

Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation	Fetal Circulation
Persistent Pulmonary Hypertension Of The Newborn	Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Persistent Foetal Circulation	Persistent Foetal Circulation Syndrome
Pfc - [Persistent Fetal Circulation] Syndrome	Pphn - [Persistent Pulmonary Hypertension Of The Newborn]
Newborn Pulmonary Hypertension	Primary Pulmonary Hypertension Of Newborn

Lesch-Nyhan Syndrome

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency	LNS
Hprt Deficiency	Complete Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency
Hypoxanthine Guanine Phosphoribosyltransferase Deficiency	X-Linked Hyperuricemia
Choreoathetosis Self-Mutilation Syndrome	Hprt1 Deficiency
Hprt Deficiency, Complete	Deficiency Of Imp Pyrophosphorylase
Hgprt Deficiency	Lesch-Nyhan Disease
Hypoxanthine Guanine Phosphoribosyltransferase 1 Deficiency	Hg-Prt Deficiency
Hypoxanthine-Guanine-Phosphoribosyltransferase Deficiency	Lesch - Nyhan Syndrome
Hprt1 Disorders	Lesch Nyhan Syndrome
Complete Hprt Deficiency Complete	Lesch Nyhan Disease
Complete Hprt Deficiency	Deficiency Of Guanine Phosphoribosyltransferase
Deficiency Of Hypoxanthine Phosphoribosyltransferase	Hypoxanthine Phosphoribosyltransferase Deficiency
Juvenile Gout, Choreoathetosis, Mental Retardation Syndrome	Juvenile Hyperuricemia Syndrome
Lnd	Primary Hyperuricemia Syndrome
Total Hprt Deficiency	Total Hypoxanthine-Guanine Phosphoribosyl Transferase Deficiency
X-Linked Primary Hyperuricemia	X-Linked Uric Aciduria Enzyme Defect
Hprt Complete Deficiency	Hprt Deficiency Grade Iv
Hypoxanthine Guanine Phosphoribosyltransferase Complete Deficiency	Hypoxanthine Guanine Phosphoribosyltransferase Deficiency, Grade Iv
Hypoxanthine-Guanine Phosphoribosyltransferase 1 Deficiency	Hprt - [ Hypoxanthine-Guanine Phosphoribosyltransferase] Complete Deficiency
Total Hgprt - [Hypoxanthine-Guanine Phosphoribosyltransferase] Deficiency

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SLC22A11 - solute carrier family 22 member 11 Gene

关于 SLC22A11

功能概要

SLC22A11 基因产物(2)

SLC22A11 蛋白结构

关联疾病

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SLC22A11 - solute carrier family 22 member 11 Gene

关于 SLC22A11

功能概要

SLC22A11 基因产物(2)

SLC22A11 蛋白结构

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z