2. Gene
  3. Sfn - stratifin Gene

Sfn - stratifin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Er; Mme1; Ywhas; 14-3-3

基因 ID: 55948 | 基因类型: protein coding

关于 Sfn

功能概要

Enables phosphoprotein binding activity and protein kinase binding activity. Involved in several processes, including establishment of skin barrier; positive regulation of protein export from nucleus; and regulation of epidermal cell division. Acts upstream of or within keratinocyte differentiation; negative regulation of keratinocyte proliferation; and regulation of cyclin-dependent protein serine/threonine kinase activity. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in transitional cell carcinoma and vulva squamous cell carcinoma. Orthologous to human SFN (stratifin). [provided by Alliance of Genome Resources, Apr 2022]

Sfn 基因产物(1)

mRNA Protein Name
NM_018754.2 NP_061224.2 14-3-3 protein sigma
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
17938205 MGI
enables protein binding IDA
IDA: 通过直接分析推断
18606808 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16710422 MGI
enables protein kinase binding IDA
IDA: 通过直接分析推断
10767298 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cAMP/PKA signal transduction IDA
IDA: 通过直接分析推断
18606808 MGI
involved in establishment of skin barrier IMP
IMP: 通过突变表型推断
24075906 MGI
acts upstream of or within keratinization IMP
IMP: 通过突变表型推断
6174530 MGI
acts upstream of or within keratinocyte development IGI
IGI: 通过遗传相互作用推断
24075906 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: 通过突变表型推断
16239341 MGI
acts upstream of keratinocyte proliferation IGI
IGI: 通过遗传相互作用推断
17041603 MGI
acts upstream of or within negative regulation of keratinocyte proliferation IGI
IGI: 通过遗传相互作用推断
17041603 MGI
acts upstream of or within negative regulation of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
17041603 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18606808 MGI
involved in positive regulation of cell growth IDA
IDA: 通过直接分析推断
16710422 MGI
involved in positive regulation of epidermal cell differentiation IMP
IMP: 通过突变表型推断
24075906 MGI
involved in positive regulation of protein export from nucleus IDA
IDA: 通过直接分析推断
17938205 MGI
involved in protein export from nucleus IDA
IDA: 通过直接分析推断
18606808 MGI
acts upstream of or within regulation of cell cycle IDA
IDA: 通过直接分析推断
10767298 MGI
acts upstream of or within regulation of cyclin-dependent protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
10767298 MGI
involved in regulation of epidermal cell division IMP
IMP: 通过突变表型推断
24075906 MGI
acts upstream of or within skin development IGI
IGI: 通过遗传相互作用推断
17041603 MGI
acts upstream of or within skin development IMP
IMP: 通过突变表型推断
16239341 MGI
acts upstream of stem cell proliferation IGI
IGI: 通过遗传相互作用推断
17041603 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16710422 MGI
located in nucleus IDA
IDA: 通过直接分析推断
16710422 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

14-3-3 protein sigma

14-3-3 sigma protein

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, sigma polypeptide

重组 Sfn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74438 14-3-3 sigma Protein, Mouse O70456 (M1-S248) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-132242 DL-Sulforaphane N-acetyl-L-cysteine 99.90% 否
HY-RS12769 SFN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sfn NCBI NCBI:2810
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