Bace2 - beta-site APP-cleaving enzyme 2 Gene

中文名称：β 位点 APP 裂解酶 2

种属: Mus musculus

同用名: ARP1; ASP1; BAE2; DRAP; AEPLC; ALP56; ASP21; CDA13; CEAP1; 1110059C24Rik

关于 Bace2

功能概要

该基因编码天冬氨酸蛋白酶肽酶 A1 家族的一个成员。编码的前原蛋白经过蛋白水解加工以产生活性内肽酶。这种跨膜蛋白酶催化淀粉样蛋白前体蛋白的蛋白水解，产生淀粉样蛋白 β 肽。由于胰岛素分泌增加，缺乏编码产物的小鼠表现出增加的胰腺 β 细胞质量和改善的葡萄糖耐量。 [RefSeq 提供，2016 年 7 月]

This gene encodes a member of the peptidase A1 family of aspartic proteases. The encoded preproprotein undergoes proteolytic processing to generate an active endopeptidase Enzyme. This transmembrane protease catalyzes the proteolysis of amyloid precursor protein to produce amyloid beta peptide. Mice lacking the encoded product exhibit increased pancreatic beta cell mass and improved glucose tolerance due to increased Insulin secretion. [provided by RefSeq, Jul 2016]