2. Gene
  3. PPAN - peter pan homolog Gene

PPAN - peter pan homolog Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：彼得潘同系物

种属: Homo sapiens

同用名: SSF; SSF1; SSF2; BXDC3; SSF-1

基因 ID: 56342 | 基因类型: protein coding

关于 PPAN

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,106,223-10,112,012 (from NCBI)

This gene has 8 transcripts (splice variants) and 191 orthologues. Ubiquitous expression in appendix (RPKM 9.7), spleen (RPKM 9.5) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种进化上保守的蛋白质，类似于酵母 SSF1 以及果蝇基因 peter pan (ppan) 的基因产物。已知 SSF1 参与 mRNA 剪接的第二步。 SSF1 和 ppan 都是细胞生长和增殖所必需的。据报道，该基因的外源性表达可减少某些肿瘤细胞的贴壁非依赖性生长。已发现该基因与 P2RY11/P2Y (11) 的通读转录，P2RY11/P2Y (11) 是编码 ATP 受体的相邻下游基因。这些通读转录本普遍存在，并在粒细胞分化过程中上调。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (ppan). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and ppan are essential for cell growth and proliferation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells. Read-through transcription of this gene with P2RY11/P2Y(11), an adjacent downstream gene that encodes an ATP receptor, has been found. These read-through transcripts are ubiquitously present and up-regulated during granulocyte differentiation. [provided by RefSeq, Nov 2010]

PPAN 基因产物(3)

mRNA Protein Name
NM_001346139.1 NP_001333068.1 suppressor of SWI4 1 homolog isoform 2
NM_001346141.1 NP_001333070.1 suppressor of SWI4 1 homolog isoform 4
NM_020230.7 NP_064615.3 suppressor of SWI4 1 homolog isoform 1
基因本体论
  • 细胞组分
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15302935 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PPAN 蛋白结构

Brix

Brix: Brix domain (33 - 286)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
蛋白主名 其他名称

suppressor of SWI4 1 homolog

brix domain-containing protein 3

关联疾病

疾病名称 别名
Narcolepsy

Paroxysmal Sleep

Gelineau Syndrome

Narcoleptic Syndrome

Narcolepsy-Cataplexy Syndrome

Cataplexy And Narcolepsy

Narcolepsy, Without Cataplexy

Gelineau'S Syndrome

Narcolepsy With Or Without Cataplexy

Narcolepsy Nos
Neurodegeneration With Brain Iron Accumulation 4

NBIA4

Mpan

Mitochondrial Protein-Associated Neurodegeneration

Nbia Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Due To C19orf12 Mutation

Neurodegeneration With Brain Iron Accumulation Type 4

Mitochondrial Membrane Protein Associated Neurodegeneration

Neurodegeneration, With Brain Iron Accumulation, Type 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS10916 PPAN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10917 Ppan Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10918 Ppan Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PPAN MGD MGI:2178445
Rattus norvegicus PPAN RGD RGD:1306325
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