2. Gene
  3. MMP26 - matrix metallopeptidase 26 Gene

MMP26 - matrix metallopeptidase 26 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品

中文名称：基质金属肽酶 26

种属: Homo sapiens

基因 ID: 56547 | 基因类型: protein coding

关于 MMP26

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:4,704,784-4,992,429 (from NCBI)

This gene has 3 transcripts (splice variants), 513 orthologues and 23 paralogues. Restricted expression toward endometrium (RPKM 7.9).

功能概要

基质金属蛋白酶 (MMP) 家族的蛋白质参与正常生理过程 (如胚胎发育、繁殖和组织重塑) 以及疾病过程 (如关节炎和转移) 中细胞外基质的分解。编码的前原蛋白经过蛋白水解处理以产生成熟酶。这种酶可以降解 IV 型胶原蛋白、纤连蛋白、纤维蛋白原和 β-酪蛋白，并通过裂解激活基质金属蛋白酶 9。该蛋白质与大多数 MMP 家族成员的不同之处在于它缺乏保守的 C 末端蛋白质结构域。编码的蛋白质可能促进多种人类癌症的细胞侵袭。[RefSeq 提供，2016 年 5 月]

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme may degrade collagen type IV, fibronectin, fibrinogen, and beta-casein, and activate matrix metalloproteinase-9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The encoded protein may promote cell invasion in multiple human cancers. [provided by RefSeq, May 2016]

MMP26 基因产物(2)

mRNA Protein Name
NM_001384608.1 NP_001371537.1 matrix metalloproteinase-26 isoform 2
NM_021801.5 NP_068573.2 matrix metalloproteinase-26 isoform 1 preproprotein
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
23569462 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MMP26 蛋白结构

Peptidase_M10

Peptidase_M10: Matrixin (98 - 253)

  • 0
  • 100
  • 200
  • 261 a.a.
蛋白主名 其他名称

matrix metalloproteinase-26

MMP-26

重组 MMP26 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76498 MMP-26 Protein, Human Q9NRE1 (T90-P261) ≥95%

关联疾病

疾病名称 别名
Endometrial Hyperplasia
Pyoderma Gangrenosum

Phagedenic Pyoderma

Phagedena Geometric
Pyoderma
Endometrial Cancer

Endometrial Carcinoma

Endometrial Neoplasm

Malignant Neoplasm Of Endometrium

Endometrioid Carcinoma

Endometrial Neoplasms

Carcinoma, Endometrioid

Endometrial Cancer, Familial

Endometrial Carcinoma, Somatic

Endometrial Cancer, Susceptibility To

Endometrial Ca

Malignant Endometrial Neoplasm

Neoplasm Of Endometrium

Primary Malignant Neoplasm Of Endometrium

Tumor Of Endometrium

Carcinoma Of The Endometrium

Endometrioid Carcinoma Of Female Reproductive System

ENDMC

Carcinoma Endometrioid

Endometrial Cancers

Cancer, Endometrial

Uterine Corpus Cancer
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P2682 MMP-8/MMP-26 Fluorogenic substrate / 否
HY-P3098 Mca-P-Cha-G-Nva-HA-Dap(DNP)-NH2 / 否
HY-RS08545 MMP26 Human Pre-designed siRNA Set A Pre-designed Sets / 否
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