PSG2 - pregnancy specific beta-1-glycoprotein 2 Gene

中文名称：妊娠特异性 β-1-糖蛋白 2

种属: Homo sapiens

同用名: CEA; PSG1; PSBG2

基因 ID: 5670 | 基因类型: protein coding

关于 PSG2

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,064,209-43,082,701 (from NCBI)

This gene has 4 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 263.6).

功能概要

人类妊娠特异性糖蛋白 (PSG) 是一个由胎盘滋养细胞大量合成并在妊娠期间释放到母体循环中的蛋白质家族。几个 PSG 基因的分子克隆和分析表明，PSG 形成癌胚抗原 (CEA) 基因家族的一个亚组，属于免疫球蛋白基因超家族。 CEA 家族的成员由一个 N 结构域组成，其结构与免疫球蛋白可变结构域相似，随后是数量可变的免疫球蛋白恒定样 A 和/或 B 结构域。大多数 PSG 具有 arg-gly-asp (RGD) 基序，它已被证明在 N 末端结构域中充当多种整合素的粘附识别信号 (Teglund 等人总结，1994 [PubMed 7851896]) 。有关 PSG 基因家族的其他一般信息，请参阅 PSG1 (MIM 176390) 。[OMIM 提供，2009 年 10 月]

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

PSG2 基因产物(1)

mRNA	Protein	Name
NM_031246.4	NP_112536.2	pregnancy-specific beta-1-glycoprotein 2 precursor

PSG2 蛋白结构

V-set

Ig_2

0
100
200
300
335 a.a.

蛋白主名

其他名称

pregnancy-specific beta-1-glycoprotein 2

PS-beta-E

重组 PSG2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71106	PSG2 Protein, Human (HEK293, His)	P11465 (Q35-T335)	≥95%

关联疾病

疾病名称

别名

Secretory Meningioma

Meningioma

Cardiomyopathy, Dilated, 1x

Dilated Cardiomyopathy 1x	CMD1X
Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness	Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness
Cardiomyopathy, Dilated 1x	Cardiomyopathy, Dilated, Type 1x

Obstructive Jaundice

Jaundice, Obstructive	Cholestatic Jaundice
Cholestatic Jaundice Syndrome	Obstructive Hyperbilirubinemia
Jaundice Obstructive	Jaundice Cholestatic

Pericarditis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Fiedler'S Myocarditis

Isolated Myocarditis	Fiedler Myocarditis
Idiopathic Myocarditis

Pleural Tuberculosis

Pearly Disease	Tuberculosis Of Pleura
Tuberculous Pleurisy	Tuberculous Pleurisy In Primary Progressive Tuberculosis
Tuberculous Pleuritis	Pleurisy Tuberculous
Tuberculosis, Pleural	Serosal Tuberculosis Of Cattle

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Medullary Thyroid Cancer
Fmtc	Mtc1
Thyroid Cancer, Medullary	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Central Sleep Apnea

Central Sleep Apnea Syndrome	Sleep Apnea, Central
Primary Central Sleep Apnea	Central Sleep Apnea, Primary
Central Sleep Apnoea Syndrome	Csa - [Central Sleep Apnoea]
Csas - [Central Sleep Apnoea Syndrome]	Central Sleep Apnoea Due To Substances Including Medications

Twin-To-Twin Transfusion Syndrome

Twin To Twin Transfusion Syndrome	Twin Twin Transfusion Syndrome
Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin	Fetal Hemorrhage Into Co-Twin
Twin To Twin Transfusion	Twin-To-Twin Blood Transfer
Fetal Transfusion Syndrome	Fetofetal Transfusion Syndrome
Ttts	Feto-Fetal Transfusion Syndrome
Fetofetal Transfusion	Fetus-To-Fetus Placental Transfusion Syndrome

Microinvasive Gastric Cancer

Early Gastric Cancer

Surface Gastric Cancer

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

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PSG2 - pregnancy specific beta-1-glycoprotein 2 Gene

关于 PSG2

功能概要

PSG2 基因产物(1)

PSG2 蛋白结构

重组 PSG2 蛋白

关联疾病

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PSG2 - pregnancy specific beta-1-glycoprotein 2 Gene

关于 PSG2

功能概要

PSG2 基因产物(1)

PSG2 蛋白结构

重组 PSG2 蛋白

关联疾病

相关产品

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z