2. Gene
  3. PARP11 - poly(ADP-ribose) polymerase family member 11 Gene

PARP11 - poly(ADP-ribose) polymerase family member 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：聚 (ADP-核糖) 聚合酶家族成员 11

种属: Homo sapiens

同用名: ARTD11; MIB006; C12orf6

基因 ID: 57097 | 基因类型: protein coding

关于 PARP11

Cytogenetic location: 12p13.32 Genomic coordinates (GRCh38): 12:3,808,861-3,873,399 (from NCBI)

This gene has 8 transcripts (splice variants), 259 orthologues and 8 paralogues. Ubiquitous expression in prostate (RPKM 3.6), testis (RPKM 3.6) and 25 other tissues.

功能概要

启用 NAD+ ADP-核糖基转移酶活性和蛋白质 ADP-核糖基酶活性。参与蛋白质自身-ADP-核糖基化和蛋白质单-ADP-核糖基化。位于胞质溶胶中；核体；和核膜。 [由基因组资源联盟提供，2022 年 4 月]

Enables NAD+ ADP-ribosyltransferase activity and protein ADP-ribosylase activity. Involved in protein auto-ADP-ribosylation and protein mono-ADP-ribosylation. Located in cytosol; nuclear body; and nuclear envelope. [provided by Alliance of Genome Resources, Apr 2022]

PARP11 基因产物(3)

mRNA Protein Name
NM_001286521.2 NP_001273450.1 protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_001286522.2 NP_001273451.1 protein mono-ADP-ribosyltransferase PARP11 isoform b
NM_020367.6 NP_065100.2 protein mono-ADP-ribosyltransferase PARP11 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD+-protein ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25043379 GOA
enables NAD+-protein poly-ADP-ribosyltransferase activity IDA
IDA: 通过直接分析推断
25673562 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in protein auto-ADP-ribosylation IDA
IDA: 通过直接分析推断
25043379 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear envelope IDA
IDA: 通过直接分析推断
25673562 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PARP11 蛋白结构

WWE

WWE: WWE domain (35 - 106)

PARP

PARP: Poly(ADP-ribose) polymerase catalytic domain (137 - 337)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
蛋白主名 其他名称

protein mono-ADP-ribosyltransferase PARP11

ADP-ribosyltransferase diphtheria toxin-like 11

关联疾病

疾病名称 别名
Osteogenesis Imperfecta, Type Xx

OI20

Osteogenesis Imperfecta Type 20

Osteogenesis Imperfecta, Type 20

Osteogenesis Imperfecta Type Xx

Osteogenesis Imperfecta 20
Arthrogryposis, Renal Dysfunction, And Cholestasis 1

Arc Syndrome

ARCS1

Arthrogryposis Renal Dysfunction Cholestasis Syndrome

Arthrogryposis-Renal Dysfunction-Cholestasis Syndrome

Arcs

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, And Cholestasis

Arthrogryposis-Renal Dysfunction-Cholestasis

Arthrogryposis - Renal Dysfunction - Cholestasis

Arthrogryposis Multiplex Congenita, Renal Dysfunction, And Cholestasis

Arthrogryposis, Renal Dysfunction And Cholestasis Syndrome 1

Arthrogryposis Renal Dysfunction And Cholestasis 1

Arthrogryposis With Renal Dysfunction And Cholestasis Syndrome

Arthrogryposis, Renal Dysfunction, Cholestasis, Type 1

Kidney Failure

Renal Insufficiency
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125218 PARP11 inhibitor ITK7 Inhibitor 99.77% 否
HY-148566 OUL232 Inhibitor 99.86% 否
HY-RS10053 PARP11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PARP11 MGD MGI:2141505
Rattus norvegicus PARP11 RGD RGD:1561791
Bos taurus PARP11 VGNC VGNC:49073
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z