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  2. TAS2R38 - taste 2 receptor member 38 Gene

TAS2R38 - taste 2 receptor member 38 Gene

中文名称:味觉 2 受体成员 38

种属: Homo sapiens

同用名: PTC; T2R38; T2R61; THIOT

基因 ID: 5726 | 基因类型: protein coding

关于 TAS2R38

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:141,972,631-141,973,773 (from NCBI)

This gene has 1 transcript (splice variant), 156 orthologues, 23 paralogues and is associated with 1 phenotype.

功能概要

该基因编码一个七次跨膜 G 蛋白偶联受体,该受体控制对芥子油苷的味觉能力,芥子油苷是一种在芸苔属植物中发现的苦味化合物家族。合成化合物苯硫脲 (PTC) 和 6-正丙基硫氧嘧啶 (PROP) 已被确定为该受体的配体,并已用于测试该基因的遗传多样性。尽管已在世界范围内鉴定出该基因的几种等位基因形式,但在非洲以外发现了两种主要的常见形式 (品尝者和非品尝者) 。这些等位基因在三个核苷酸位置不同,导致蛋白质中的氨基酸发生变化 (A49P、A262V 和 V296I) ,氨基酸组合 PAV 识别味觉变体 (AVI 识别非味觉变体) 。[RefSeq 提供,2009 年 10 月]

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste Glucosinolates, a family of bitter-tasting compounds found in Plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

TAS2R38 基因产物(1)

mRNA Protein Name
NM_176817.5 NP_789787.5 taste receptor type 2 member 38
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bitter taste receptor activity IDA
IDA: 通过直接分析推断
20022913 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in detection of chemical stimulus involved in sensory perception of bitter taste IDA
IDA: 通过直接分析推断
20022913 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
12379855 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAS2R38 蛋白结构

TAS2R

TAS2R: Taste receptor protein (TAS2R) (14 - 314)

  • 0
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  • 333 a.a.
蛋白主名 其他名称

taste receptor type 2 member 38

PTC bitter taste receptor

关联疾病

疾病名称 别名
Thiourea Tasting

Phenylthiocarbamide Tasting

THIOT

Dental Caries

Dental Caries Extending Into Pulp

Dental Caries Of Smooth Surface

Dental Caries Pit And Fissure

Smooth Surface Dental Caries

Dental Decay

Carious Teeth

Dental Cavity

Saprodontia

Teeth Decayed

Tooth Caries

Tooth Decay

Submandibular Gland Cancer

Malignant Neoplasm Of Submaxillary Gland

Malignant Tumor Of Submandibular Gland

Malignant Tumor Of The Submandibular Gland

Submandibular Gland Disease

Submandibular Gland Diseases

Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TAS2R38 VGNC VGNC:78266
Felis catus TAS2R38 VGNC VGNC:69134
Rattus norvegicus TAS2R38 RGD RGD:1560649
Canis familiaris TAS2R38 VGNC VGNC:47117
Bos taurus TAS2R38 VGNC VGNC:35612
Mus musculus TAS2R38 MGD MGI:2681306