2. Gene
  3. NDRG2 - NDRG family member 2 Gene

NDRG2 - NDRG family member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：NDRG 家族成员 2

种属: Homo sapiens

同用名: SYLD

基因 ID: 57447 | 基因类型: protein coding

关于 NDRG2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,016,763-21,070,872 (from NCBI)

This gene has 77 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 217.5), brain (RPKM 177.5) and 19 other tissues.

功能概要

该基因是属于 α/β 水解酶超家族的 N-myc 下调基因家族的成员。该基因编码的蛋白质是一种细胞质蛋白质，可能在神经突生长中发挥作用。该基因可能参与胶质母细胞瘤的致癌作用。可变剪接导致多个转录本变体。[RefSeq 提供，2017 年 8 月]

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

NDRG2 基因产物(27)

mRNA Protein Name
NM_001282211.2 NP_001269140.1 protein NDRG2 isoform c
NM_001282212.2 NP_001269141.1 protein NDRG2 isoform d
NM_001282213.2 NP_001269142.1 protein NDRG2 isoform b
NM_001282214.2 NP_001269143.1 protein NDRG2 isoform b
NM_001282215.2 NP_001269144.1 protein NDRG2 isoform e
NM_001282216.2 NP_001269145.1 protein NDRG2 isoform f
NM_001320329.2 NP_001307258.1 protein NDRG2 isoform a
NM_001354558.2 NP_001341487.1 protein NDRG2 isoform g
NM_001354559.2 NP_001341488.1 protein NDRG2 isoform a
NM_001354560.2 NP_001341489.1 protein NDRG2 isoform h
NM_001354561.2 NP_001341490.1 protein NDRG2 isoform b
NM_001354562.2 NP_001341491.1 protein NDRG2 isoform a
NM_001354564.2 NP_001341493.1 protein NDRG2 isoform i
NM_001354565.2 NP_001341494.1 protein NDRG2 isoform a
NM_001354566.1 NP_001341495.1 protein NDRG2 isoform a
NM_001354567.2 NP_001341496.1 protein NDRG2 isoform a
NM_001354568.2 NP_001341497.1 protein NDRG2 isoform b
NM_001354569.1 NP_001341498.1 protein NDRG2 isoform b
NM_001354570.2 NP_001341499.1 protein NDRG2 isoform a
NM_016250.3 NP_057334.1 protein NDRG2 isoform b
NM_201535.2 NP_963293.1 protein NDRG2 isoform a
NM_201536.2 NP_963294.1 protein NDRG2 isoform b
NM_201537.2 NP_963831.1 protein NDRG2 isoform a
NM_201538.2 NP_963832.1 protein NDRG2 isoform b
NM_201539.2 NP_963833.1 protein NDRG2 isoform a
NM_201540.2 NP_963834.1 protein NDRG2 isoform a
NM_201541.2 NP_963835.1 protein NDRG2 isoform b
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21217774 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NDRG2 蛋白结构

Ndr

Ndr: Ndr family (41 - 318)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
蛋白主名 其他名称

protein NDRG2

N-myc downstream regulator 2

NDRG2 抗体

目录号 产品名 应用 反应物种
HY-P83550 NDRG2 Antibody (YA3295) WB, IHC-F, IHC-P, ICC/IF, IP Mouse, Rat

关联疾病

疾病名称 别名
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Charcot-Marie-Tooth Disease, Type 4d

Charcot-Marie-Tooth Disease Type 4d

CMT4D

Hmsnl

Hmsn4d

Charcot-Marie-Tooth Neuropathy Type 4d

Hereditary Motor And Sensory Neuropathy Lom Type

Hmsn-Lom

Neuropathy, Hereditary Motor And Sensory, Lom Type

Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d

Charcot-Marie-Tooth Neuropathy, Type 4d

Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d

Hmsn Lom Type

Hmsn, Lom Type

Hereditary Motor And Sensory Neuropathy, Lom Type

Charcot-Marie-Tooth Disease 4d

Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d

Hereditary Motor And Sensory Neuropathy Ivd

Hmsn Ivd
Intracranial Meningioma

Meningioma
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100443 PX20606 Agonist / 否
HY-P10359 TAT-QFNP12 Inhibitor / 否
HY-RS09115 NDRG2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NDRG2 MGD MGI:1352498
Canis familiaris NDRG2 VGNC VGNC:43679
Rattus norvegicus NDRG2 RGD RGD:621874
Felis catus NDRG2 VGNC VGNC:63754
Macaca mulatta NDRG2 VGNC VGNC:74953
Bos taurus NDRG2 VGNC VGNC:50007
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