Casp9 - caspase 9 Gene

中文名称：半胱天冬酶 9

种属: Rattus norvegicus

同用名: Mch6; Apaf3; Casp9_v1; Ice-Lap6; Casp-9-CTD

关于 Casp9

功能概要

该基因编码的蛋白可启动半胱氨酸型肽酶活性。参与多个过程，包括胶质细胞凋亡过程；对雌二醇的反应；和对缺血的反应。位于胞质溶胶中；线粒体；和核。用于研究恶变前的肿瘤。多种疾病的生物标志物，包括脑血管疾病（多种）；心脏病（多种）；肾脏疾病（多发）；神经退行性疾病（多种）；和创伤后应激障碍。该基因的人类直系同源物与多种疾病有关，包括帕金森病；结直肠癌；肺非小细胞癌；胰腺癌;和 2 型糖尿病。与人类 CASP9（caspase 9）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type peptidase activity. Involved in several processes, including glial cell apoptotic process; response to estradiol; and response to ischemia. Located in cytosol; mitochondrion; and nucleus. Used to study pre-malignant neoplasm. Biomarker of several diseases, including cerebrovascular disease (multiple); heart disease (multiple); kidney disease (multiple); neurodegenerative disease (multiple); and post-traumatic stress disorder. Human ortholog(s) of this gene implicated in several diseases, including Parkinson's disease; colorectal cancer; lung non-small cell carcinoma; pancreatic cancer; and type 2 diabetes mellitus. Orthologous to human CASP9 (Caspase 9). [provided by Alliance of Genome Resources, Apr 2022]