2. Gene
  3. Crhr1 - corticotropin releasing hormone receptor 1 Gene

Crhr1 - corticotropin releasing hormone receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：促肾上腺皮质激素释放激素受体 1

种属: Rattus norvegicus

同用名: CRF1; CRF-R; CRFR1; CRH-R; CRF-R1; CRFR-1; CRH-R1; CRF-R-1; CRH-R 1; CRH-R-1

基因 ID: 58959 | 基因类型: protein coding

关于 Crhr1

Primary_assembly 10: 89,040,203-89,083,481 forward strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 239 orthologues, 42 paralogues and is associated with 29 phenotypes. Restricted expression toward (RPKM 31.6).

功能概要

该基因编码 G 蛋白偶联受体家族的一个成员。编码的蛋白质是促肾上腺皮质激素释放因子 (CRH) 和尿皮质素 (UCN) 的受体。这种蛋白质与 CRH 和 UCN 的相互作用触发 G 蛋白偶联信号。这种蛋白质在介导 CRH 引起的抑郁和焦虑效应中起着关键作用。已发现该基因的可变剪接转录物变体。 [RefSeq 提供，2014 年 9 月]

This gene encodes a member of the G-protein coupled receptor family. The encoded protein is a receptor for corticotropin-releasing factor (CRH) and urocortin (UCN). The interaction of this protein with CRH and UCN triggers G-protein coupled signaling. This protein plays a pivotal role in mediating the CRH-elicited effects in depression and anxiety. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Crhr1 基因产物(2)

mRNA Protein Name
NM_001301812.2 NP_001288741.2 corticotropin-releasing factor receptor 1 isoform 2 precursor
NM_030999.5 NP_112261.2 corticotropin-releasing factor receptor 1 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IDA
IDA: 通过直接分析推断
11902119 RGD
enables G-protein alpha-subunit binding IPI
IPI: 通过物理相互作用推断
20548297 RGD
enables corticotropin-releasing hormone binding IDA
IDA: 通过直接分析推断
12942143 RGD
enables corticotropin-releasing hormone receptor activity IDA
IDA: 通过直接分析推断
12942143 RGD
enables peptide binding IDA
IDA: 通过直接分析推断
15049707 RGD
enables peptide binding IPI
IPI: 通过物理相互作用推断
15932935 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
24290358 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
20548297 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15932935 RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11784785 RGD
involved in behavioral response to cocaine IMP
IMP: 通过突变表型推断
21813699 RGD
involved in behavioral response to pain IMP
IMP: 通过突变表型推断
17550594 RGD
involved in epithelial cell differentiation IMP
IMP: 通过突变表型推断
20551459 RGD
involved in feeding behavior IMP
IMP: 通过突变表型推断
12559107 RGD
involved in hypothalamus development IEP
IEP: 通过表达模式推断
20002962 RGD
involved in locomotory exploration behavior IMP
IMP: 通过突变表型推断
9299637 RGD
involved in long-term synaptic potentiation IMP
IMP: 通过突变表型推断
19376201 RGD
involved in memory IMP
IMP: 通过突变表型推断
15932935 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: 通过突变表型推断
12606499 RGD
involved in negative regulation of feeding behavior IMP
IMP: 通过突变表型推断
14512273 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11784785 RGD
involved in neuropeptide signaling pathway IDA
IDA: 通过直接分析推断
11784785 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
15932935 RGD
involved in positive regulation of cAMP/PKA signal transduction IMP
IMP: 通过突变表型推断
20682782 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
16513211 RGD
involved in positive regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
18209484 RGD
involved in regulation of synaptic plasticity IMP
IMP: 通过突变表型推断
17079348 RGD
involved in response to electrical stimulus IMP
IMP: 通过突变表型推断
17015825 RGD
involved in response to hypoxia IMP
IMP: 通过突变表型推断
16099461 RGD
involved in response to immobilization stress IEP
IEP: 通过表达模式推断
21664419 RGD
involved in visual learning IMP
IMP: 通过突变表型推断
15932935 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
12911751 RGD
located in dendrite IDA
IDA: 通过直接分析推断
12911751 RGD
NOT located in dendritic spine IDA
IDA: 通过直接分析推断
12911751 RGD
located in multivesicular body IDA
IDA: 通过直接分析推断
12911751 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
12911751 RGD
located in trans-Golgi network IDA
IDA: 通过直接分析推断
12911751 RGD
located in vesicle IDA
IDA: 通过直接分析推断
12911751 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

corticotropin-releasing factor receptor 1

corticotrophin releasing hormone receptor 1

corticotropin releasing hormone 1

Crhr1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Crhr1 P35353 Ucn Rattus norvegicus P55090
Crosslink
24290358
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103377 Antalarmin hydrochloride Antagonist 99.87% 否
HY-124475 Antalarmin Antagonist 98.29% 否
HY-12131 DMP 696 Antagonist 99.03% 否
HY-RS03168 CRHR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03169 Crhr1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS03170 Crhr1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Crhr1 NCBI NCBI:1394
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