Carm1 - coactivator-associated arginine methyltransferase 1 Gene

中文名称：共激活因子相关精氨酸甲基转移酶 1

种属: Mus musculus

同用名: Prmt4; m9Bei

关于 Carm1

功能概要

该基因编码的蛋白可启动多种功能，包括赖氨酸乙酰化组蛋白结合活性；核受体共激活因子活性；和蛋白质-精氨酸 N-甲基转移酶活性。参与多个过程，包括组蛋白 H3-R17 甲基化；脂肪细胞分化的正调节；细胞内雌激素受体信号通路的调控。作用于多个过程的上游或内部，包括细胞内雌激素受体信号通路；生长板软骨细胞增殖的调节；和转录调控，DNA 模板化。位于细胞质和细胞核中。 RNA 聚合酶 II 转录调节复合物的一部分。以多种结构表达，包括鳃弓；中枢神经系统;性腺;肢芽;和感觉器官。与人类 CARM1（共激活剂相关的精氨酸甲基转移酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including lysine-acetylated histone binding activity; nuclear receptor coactivator activity; and protein-arginine N-methyltransferase activity. Involved in several processes, including histone H3-R17 methylation; positive regulation of fat cell differentiation; and regulation of intracellular Estrogen Receptor signaling pathway. Acts upstream of or within several processes, including intracellular Estrogen Receptor signaling pathway; regulation of growth plate cartilage chondrocyte proliferation; and regulation of transcription, DNA-templated. Located in cytosol and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including branchial arch; central nervous system; gonad; limb bud; and sensory organ. Orthologous to human CARM1 (coactivator associated arginine methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]