Erbb4 - erb-b2 receptor tyrosine kinase 4 Gene

中文名称：erb-b2 受体酪氨酸激酶4

种属: Rattus norvegicus

关于 Erbb4

功能概要

预计该基因编码的蛋白具有多种功能，包括表皮生长因子受体结合活性；蛋白质同二聚化活性；和跨膜受体蛋白酪氨酸激酶活性。参与多个过程，包括动物器官发育； GABAergic 突触传递的正向调节；积极调节葡萄糖输入。位于几种细胞成分中，包括小窝；突触后密度；和突触后膜。与抑制性突触共定位。用于研究视觉性癫痫。充血性心力衰竭的生物标志物；正中神经病变;神经根病;和精神分裂症。该基因的人类直系同源物与 19 型肌萎缩侧索硬化有关；结直肠癌；食道鳞状细胞癌；肝细胞癌；和肺腺癌。与人 ERBB4（erb-b2 受体酪氨酸激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including epidermal growth factor receptor binding activity; protein homodimerization activity; and transmembrane receptor protein tyrosine kinase activity. Involved in several processes, including animal organ development; positive regulation of GABAergic synaptic transmission; and positive regulation of glucose import. Located in several cellular components, including caveola; postsynaptic density; and postsynaptic membrane. Colocalizes with inhibitory synapse. Used to study visual epilepsy. Biomarker of congestive heart failure; median neuropathy; radiculopathy; and schizophrenia. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 19; colorectal cancer; esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human ERBB4 (erb-b2 receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]