HRH4 - histamine receptor H4 Gene

中文名称：组胺受体 H4

种属: Homo sapiens

同用名: H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105

基因 ID: 59340 | 基因类型: protein coding

关于 HRH4

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,460,637-24,479,974 (from NCBI)

This gene has 2 transcripts (splice variants), 105 orthologues and 25 paralogues. Low expression observed in reference dataset.

功能概要

组胺是一种普遍存在的信使分子，从肥大细胞、肠嗜铬样细胞和神经元中释放出来。它的各种作用由组胺受体家族介导，该家族是 G 蛋白偶联受体超家族的一个子集。该基因编码主要在造血细胞中表达的组胺受体。该蛋白质被认为在炎症和过敏反应中发挥作用。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 5 月]

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a Histamine Receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

HRH4 基因产物(3)

mRNA	Protein	Name
NM_021624.4	NP_067637.2	histamine H4 receptor isoform 1
NM_001160166.2	NP_001153638.1	histamine H4 receptor isoform 3
NM_001143828.2	NP_001137300.1	histamine H4 receptor isoform 2

HRH4 蛋白结构

7tm_1

0
100
200
300
390 a.a.

蛋白主名

其他名称

histamine H4 receptor

G-protein coupled receptor 105	SP9144
pfi-013

关联疾病

疾病名称

别名

Chronic Conjunctivitis

Meniere Disease

Meniere'S Disease	Otogenic Vertigo
Ménière Disease	Ménière'S Disease
Mnire'S Vertigo	Auditory Vertigo
Aural Vertigo	Meniere'S Syndrome
Ménière'S Vertigo	Primary Endolymphatic Hydrops
Menieres Disease	Vertigo, Aural
Labyrinth Hydrops	Labyrinthine Hydrops
Labyrinthine Vertigo	Ménière Syndrome
Ménière Vertigo	Idiopathic Endolymphatic Hydrops

Paraneoplastic Cerebellar Degeneration

Pcd	Paraneoplastic Cerebellar Ataxia
Rapidely Progressive Cerebellar Syndrome	Subacute Cerebellar Degeneration

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Pericarditis

Allergic Conjunctivitis

Conjunctivitis Allergic	Conjunctivitis, Allergic
Allergen-Induced Conjunctivitis	Seasonal Allergic Conjunctivitis
Perennial Allergic Conjunctivitis	Spring Conjunctivitis
Acute Allergic Conjunctivitis

Allergic Disease

Hypersensitivity	Allergic Hypersensitivity Disease
Allergic Condition	Allergic Reaction
Allergic Disposition

Nasal Cavity Disease

Disorder Of Nasal Cavity

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06368	HRH4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06369	Hrh4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06370	Hrh4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HRH4	VGNC	VGNC:41788
Macaca mulatta	HRH4	VGNC	VGNC:73404
Felis catus	HRH4	VGNC	VGNC:62841
Bos taurus	HRH4	VGNC	VGNC:29956
Mus musculus	HRH4	MGD	MGI:2429635
Rattus norvegicus	HRH4	RGD	RGD:620631

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HRH4 - histamine receptor H4 Gene

关于 HRH4

功能概要

HRH4 基因产物(3)

HRH4 蛋白结构

关联疾病

直系同源

热门区域

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HRH4 - histamine receptor H4 Gene

关于 HRH4

功能概要

HRH4 基因产物(3)

HRH4 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z