2. Gene
  3. REG1A - regenerating family member 1 alpha Gene

REG1A - regenerating family member 1 alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：重生的家族成员 1 阿尔法

种属: Homo sapiens

同用名: P19; PSP; PTP; REG; ICRF; PSPS; PSPS1

基因 ID: 5967 | 基因类型: protein coding

关于 REG1A

Cytogenetic location: 2p12 Genomic coordinates (GRCh38): 2:79,120,488-79,123,409 (from NCBI)

This gene has 4 transcripts (splice variants), 777 orthologues and 5 paralogues. Biased expression in pancreas (RPKM 5037.4), duodenum (RPKM 2788.3) and 2 other tissues.

功能概要

该基因是 Reg 基因家族的 I 型亚类成员。 Reg 基因家族是一个多基因家族，根据编码蛋白质的一级结构分为四个亚类，I、II、III 和 IV 型。该基因编码一种由外分泌胰腺分泌的蛋白质。它与胰岛细胞再生和糖尿病发生有关，并可能参与胰腺结石。 Reg 家族成员 REG1B、REGL、PAP 和该基因串联聚集在染色体 2p12 上，可能通过基因复制产生于同一祖先基因。[RefSeq 提供，2008 年 7 月]

This gene is a type I subclass member of the Reg gene family. The Reg gene family is a multigene family grouped into four subclasses, types I, II, III and IV, based on the primary structures of the encoded proteins. This gene encodes a protein that is secreted by the exocrine pancreas. It is associated with islet cell regeneration and diabetogenesis and may be involved in pancreatic lithogenesis. Reg family members REG1B, REGL, PAP and this gene are tandemly clustered on chromosome 2p12 and may have arisen from the same ancestral gene by gene duplication. [provided by RefSeq, Jul 2008]

REG1A 基因产物(1)

mRNA Protein Name
NM_002909.5 NP_002900.2 lithostathine-1-alpha precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor activity IDA
IDA: 通过直接分析推断
10526060 GOA
enables molecular function inhibitor activity IDA
IDA: 通过直接分析推断
1397886 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

REG1A 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (54 - 163)

  • 0
  • 100
  • 166 a.a.
蛋白主名 其他名称

lithostathine-1-alpha

REG-1-alpha

REG1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
REG1A P05451 REG1B Homo sapiens P48304
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 REG1A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71078 REG-1 alpha/REG1A Protein, Human (HEK293, His) P05451 (Q23-N166) ≥95%

关联疾病

疾病名称 别名
Acinar Cell Carcinoma

Acinic Cell Carcinoma

Acinic Cell Tumor

Carcinoma Acinar Cell

Carcinoma, Acinar Cell

Acinar Cell Tumor
Pancreatitis

Mumps Pancreatitis
Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases
Pancreatitis, Hereditary

Hereditary Pancreatitis

Chronic Pancreatitis

Hereditary Chronic Pancreatitis

Hp

Pancreatitis, Chronic, Susceptibility To

PCTT

Hpc

Pancreatitis, Chronic

Pancreatitis, Chronic, Protection Against

Autosomal Dominant Hereditary Pancreatitis

Familial Pancreatitis

Cp

Pancreatitis Hereditary
Cystic Echinococcosis

Echinococcus Granulosus Infection

Echinococcus Granulosus Infection Of Lung

Echinococcus Granulosus

Echinococcus Granulosus Infection Of Thyroid

Echinococcus Granulosus Infectious Disease

Echinococcus Granulosus Infectious Disease Of Liver

Echinococcus Granulosus Infectious Disease Of Thyroid

Liver Echinococcus Granulosus

Lung Echinococcus Granulosus

Thyroid Echinococcus Granulosus

Unilocular Echinococcosis

Unilocular Hydatid Disease

Hydatid Disease

Hydatidosis

Echinococcosis
Bone Angioendothelial Sarcoma

Osseous Hemangiosarcoma

Bone Angiosarcoma
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diabetes Mellitus

Diabetes
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11818 REG1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus REG1A RGD RGD:3552
Macaca fascicularis REG1A NCBI
Others REG1A NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z